An open call for nano-based therapy to address COVID-19 and oncological clinical conditions

Dash, Rasmita; Sahoo, Rudra Narayan; Pattnaik, Gurudutta; Sarangi, Ashish K.; Ramana, K V; Mishra, Snehasish; Verma, Sanjeev Kumar; Mohapatra, Ranjan K.

doi:10.1097/js9.0000000000000071

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Keeping the growing demand particularly in medical applications and their universal value in view, nanoadjuvants offer tremendous prospects in biobusiness in international trade and commerce. − In light of this, it is essential to discuss and analyze the strengths and opportunities (as the positive factors), and weaknesses and threats (as the negative factors) of the commercial implications of nanoadjuvant-based vaccine development with the former as either a vaccine carrier or as a performance elicitor. Thus, a schematic presentation of the SWOT analysis is provided in Figure for better and comprehensive understanding for readers.…”

Section: Resultsmentioning

confidence: 99%

Nanoadjuvants: Promising Bioinspired and Biomimetic Approaches in Vaccine Innovation

et al. 2023

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Adjuvants are the important part of vaccine manufacturing as they elicit the vaccination effect and enhance the durability of the immune response through controlled release. In light of this, nanoadjuvants have shown unique broad spectrum advantages. As nanoparticles (NPs) based vaccines are fast-acting and better in terms of safety and usability parameters as compared to traditional vaccines, they have attracted the attention of researchers. A vaccine nanocarrier is another interesting and promising area for the development of next-generation vaccines for prophylaxis. This review looks at the various nanoadjuvants and their structure−function relationships. It compiles the state-of-art literature on numerous nanoadjuvants to help domain researchers orient their understanding and extend their endeavors in vaccines research and development.

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Section: Resultsmentioning

confidence: 99%

Nanoadjuvants: Promising Bioinspired and Biomimetic Approaches in Vaccine Innovation

et al. 2023

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“…1,2 Traditional drug delivery or systemic administration of a drug could have flaws such as nonspecific targeting, low efficacy, and inadvertent and obvious sideeffects. 3,4 The emerging field of smart drug delivery aims to design and develop delivery systems to address these flaws to target specific cells, tissues, and organs better and minimize the off-target side-effects. 5,6 The development of smart drug delivery systems has opened up new vistas for targeted drug delivery against numerous diseases including cancer, cardiovascular diseases, neurological disorders, and infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Drug delivery is a critical aspect of modern medicine that ensures effective and safe administration of therapeutic agents to the target site in the body 1,2 . Traditional drug delivery or systemic administration of a drug could have flaws such as nonspecific targeting, low efficacy, and inadvertent and obvious side‐effects 3,4 . The emerging field of smart drug delivery aims to design and develop delivery systems to address these flaws to target specific cells, tissues, and organs better and minimize the off‐target side‐effects 5,6 …”

Section: Introductionmentioning

confidence: 99%

Current approaches in smart nano‐inspired drug delivery: A narrative review

Boppana,

Kutikuppala,

Sharma

et al. 2024

Health Science Reports

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Background and AimThe traditional drug delivery approach involves systemic administration of a drug that could be nonspecific in targeting, low on efficacy, and with severe side‐effects. To address such challenges, the field of smart drug delivery has emerged aiming at designing and developing delivery systems that can target specific cells, tissues, and organs and have minimal off‐target side‐effects.MethodsA literature search was done to collate papers and reports about the currently available various strategies for smart nano‐inspired drug delivery. The databases searched were PubMed, Scopus, and Google Scholar. Based on selection criteria, the most pertinent and recent items were included.ResultsSmart drug delivery is a cutting‐edge revolutionary intervention in modern medicines to ensure effective and safe administration of therapeutics to target sites. These hold great promise for targeted and controlled delivery of therapeutic agents to improve the efficacy with reduced side‐effects as compared to the conventional drug delivery approaches. Current smart drug delivery approaches include nanoparticles, liposomes, micelles, and hydrogels, each with its own advantages and limitations. The success of these delivery systems lies in engineering and designing them, and optimizing their pharmacokinetics and pharmacodynamics properties.ConclusionDevelopment of drug delivery systems that can get beyond various physiological and clinical barriers, as observed in conventionally administered chemotherapeutics, has been possible through recent advancements. Using multifunctional targeting methodologies, smart drug delivery tries to localize therapy to the target location, reduces cytotoxicity, and improves the therapeutic index. Rapid advancements in research and development in smart drug delivery provide wider and more promising avenues to guarantee a better healthcare system, improve patient outcomes, and achieve higher levels of effective medical interventions like personalized medicine.

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An open call for nano-based therapy to address COVID-19 and oncological clinical conditions

Cited by 2 publications

References 21 publications

Nanoadjuvants: Promising Bioinspired and Biomimetic Approaches in Vaccine Innovation

Nanoadjuvants: Promising Bioinspired and Biomimetic Approaches in Vaccine Innovation

Current approaches in smart nano‐inspired drug delivery: A narrative review

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