2016
DOI: 10.1002/ieam.1763
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An open framework for automated chemical hazard assessment based on GreenScreen for Safer Chemicals: A proof of concept

Abstract: GreenScreen® for Safer Chemicals is a framework for comparative chemical hazard assessment. It is the first transparent, open and publicly accessible framework of its kind, allowing manufacturers and governmental agencies to make informed decisions about the chemicals and substances used in consumer products and buildings. In the GreenScreen® benchmarking process, chemical hazards are assessed and classified based on 18 hazard endpoints from up to 30 different sources. The result is a simple numerical benchmar… Show more

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Cited by 7 publications
(8 citation statements)
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“…In vitro and in silico data, however, have different limitations and tools are needed to understand how to appropriately address these factors. Many State and federal agencies use GreenScreen® for chemical hazard assessment 35 . GreenScreen® is a chemical hazard assessment approach that provides users with guidance on integrating multiple data sources.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In vitro and in silico data, however, have different limitations and tools are needed to understand how to appropriately address these factors. Many State and federal agencies use GreenScreen® for chemical hazard assessment 35 . GreenScreen® is a chemical hazard assessment approach that provides users with guidance on integrating multiple data sources.…”
Section: Discussionmentioning
confidence: 99%
“…It is important to assess all types of toxicity when considering an alternative because it would be regrettable to replace an endocrine disruptor with a carcinogen, for example. One of the benefits of ToxCast is availability of assay data for other endpoints, such as reproductive 35 and developmental toxicity 23 and neurotoxicity 35 . In vitro databases, such as ToxCast can help understand the range of molecular initiating events that are often not studied in a single in vivo study.…”
Section: Discussionmentioning
confidence: 99%
“…As of 2020, CHDC identified 22 specific human and environmental health endpoints (based on Healthy Building Network’s Pharos Chemical and Material Library) . The database is an aggregate of over 40 authoritative hazard lists integrating the GreenScreen protocol to identify the inherent hazards of chemicals across a broad range of health endpoints …”
Section: Methodsmentioning
confidence: 99%
“…Manually culling hazard endpoint data to generate a complete hazard profile takes approximately eight hours (Wehage et al 2016). Therefore the time required for data collection is a barrier for implementation of most alternative assessment methodologies such as the GreenScreen (Clean Production Action 2007).…”
Section: Generation Of Hazard Profile Scoresmentioning
confidence: 99%
“…Therefore the time required for data collection is a barrier for implementation of most alternative assessment methodologies such as the GreenScreen (Clean Production Action 2007). Wehage et al (Wehage et al 2016) developed an automated system to download GHS data from Japan's National Institute of Technology and Evaluation (NITE) website. In order for the AA methodology outlined in this paper to be successful, data will need to be mined from a wide variety of freely available websites in order to minimize data gaps and facilitate AA usability.…”
Section: Generation Of Hazard Profile Scoresmentioning
confidence: 99%