An open label naturalistic study of predictors of retention and compliance to naltrexone maintenance treatment among patients with opioid dependence

Dayal, Prabhoo; Balhara, Yatan Pal Singh; Mishra, Ashwani Kumar

doi:10.3109/14659891.2015.1021867

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…Demographic characteristics of the participants with a mean age of about 31 years, the majority being married, educated till secondary level, employed, from nuclear family, and from low incomes, is consonant with other studies on substance use from similar treatment facilities. 18 , 27 – 30 Studies from other countries also report similar profiles, except for more participants being employed in our sample. 31 – 33 Comorbid illness in less than a quarter of participants is also similar to another study from India, but a family history of substance use was reported more in that study.…”

Section: Discussionsupporting

confidence: 70%

“…We found the retention rates of patients on naltrexone to be 41.9%, which is comparable to those found by researchers from the United States, Australia, and India, who found the rates to be 44.4%, 43.8%, and 41%, respectively. 18 – 20 A few older studies have also found better retention on naltrexone than the present study. The retention rate was around 70% in a study on federal probationers in the United States 21 and 77% among a sample of opioid-dependent patients detoxified in a hospital in Spain.…”

Section: Discussionsupporting

confidence: 59%

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A Prospective Three-Months Naturalistic Follow-Up Study of Outcomes of Patients with Opioid Dependence Discharged on Buprenorphine or Oral Naltrexone

Dhawan

Chadda

Mishra

et al. 2022

Indian Journal of Psychological Medicine

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Background: Comparative studies of the naturalistic course of patients of opioid dependence on naltrexone and buprenorphine are likely to be helpful for clinical decision-making. The article aimed to report on the three-months naturalistic outcomes of patients discharged on naltrexone or buprenorphine from the same center. Methods: Patients with opioid dependence who were discharged on either naltrexone ( n = 86) or buprenorphine ( n = 30) were followed up for three months for retention in treatment. The patients were also followed up telephonically, and the Maudsley Addiction Profile was applied. Results: The days of retention in treatment were significantly higher in the buprenorphine group (69.5 versus 48.7 days, P = 0.009). Heroin use, pharmaceutical opioid use, injection drug use, involvement in illegal activity, and percentage of contact days in conflict with friends in the last 30 days reduced over three months in both the groups, while the physical and psychological quality of life improved in both the groups. Additionally, in the naltrexone group, smoked tobacco use, cannabis use, and percentage of contact days in conflict with family within the last 30 days reduced at three months compared to baseline. Conclusion: With the possible limitations of choice of medication-assisted treatment for opioid dependence being determined by the patient, and prescribing related factors and sample size constraints, the study suggests that retention outcomes may vary between naltrexone and buprenorphine, though both medications may improve several patient-related parameters. However, a true head-to-head comparison of the outcomes of buprenorphine and naltrexone in a naturalistic setting may be difficult.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 59%

A Prospective Three-Months Naturalistic Follow-Up Study of Outcomes of Patients with Opioid Dependence Discharged on Buprenorphine or Oral Naltrexone

Dhawan

Chadda

Mishra

et al. 2022

Indian Journal of Psychological Medicine

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“…[5,6] Opioid antagonists are also available for use during the long-term phase and the limited literature form the country has identified it be a feasible option for at least a subgroup of individuals with opioid use disorders. [7] Buprenorphine is being used for the management of opioid use disorder in the country since at least late 1980s. Methadone has been a late entrant, with its use starting in country in the year 2012.…”

Section: Introductionmentioning

confidence: 99%

Use of Tramadol for Management of Opioid Use Disorders: Rationale and Recommendations

Balhara

Parmar

Sarkar

2018

Journal of Neurosciences in Rural Practice

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Opioids are one of the most common illicit psychoactive substances being used in India. In fact, opioid use disorders are the most common disorder presenting to the substance use disorder treatment centers across the country. Effective and evidence-based interventions are available for management of opioid use disorders. However, the treatment for opioid use disorders remains difficult to access for most of those in need in India. The current article presents the literature on the use of tramadol for the management of opioid use disorders. It also makes recommendations on the use of tramadol for the management of opioid use disorders. Tramadol offers a viable alternative to the existing options for the management of opioid use disorders. It has been found effective when used for this indication. It offers certain major advantages such as easy and wide availability and low abuse liability. It offers a good option to expand the treatment services for opioid use disorders across the country.

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“…Other studies have compared adherence in patients with either heroin or non‐heroin opioid use disorders and did not find a difference in retention . Third, this study followed veterans for 12 months after the index XR‐NTX injection in comparison to other studies that limited follow up to 6 months . Fourth, this study examined healthcare utilization in the year before and after the index injection and found that the number of inpatient admissions for medically managed detoxification was halved, in contrast to other work which demonstrated that XR‐NTX did not significantly change rates of healthcare utilization for opioid users .…”

Section: Discussionmentioning

confidence: 80%

Adherence to extended release naltrexone: Patient and treatment characteristics

et al. 2018

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An open label naturalistic study of predictors of retention and compliance to naltrexone maintenance treatment among patients with opioid dependence

Cited by 8 publications

References 30 publications

A Prospective Three-Months Naturalistic Follow-Up Study of Outcomes of Patients with Opioid Dependence Discharged on Buprenorphine or Oral Naltrexone

A Prospective Three-Months Naturalistic Follow-Up Study of Outcomes of Patients with Opioid Dependence Discharged on Buprenorphine or Oral Naltrexone

Use of Tramadol for Management of Opioid Use Disorders: Rationale and Recommendations

Adherence to extended release naltrexone: Patient and treatment characteristics

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