An open-label phase IB study to evaluate GSK3052230 in combination with paclitaxel and carboplatin, or docetaxel, in FGFR1-amplified non-small cell lung cancer

Morgensztern, Daniel; Karaseva, Nina; Felip, Enriqueta; Delgado, Ignacio; Burdaeva, Olga; Dómine, Manuel; Lara, Primo N.; Paik, Paul K.; Lassen, Ulrik; Орлов, С. В.; Trigo, José; Шомова, М В; Baker-Neblett, Katherine L.; Vasquez, James; Wang, Xiaowei; Li, Yan; Mitrica, Ionel; DeYoung, M. Phillip; Garrido, Pilar

doi:10.1016/j.lungcan.2019.08.011

Cited by 19 publications

(12 citation statements)

References 26 publications

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“…For example, FP-1039 (GSK3052230) is a soluble fusion of the extracellular ligand-binding domain of FGFR1 linked to a modified hinge and native Fc regions of IgG1. FP-1039 was well tolerated, even when used in combination with chemotherapy for lung cancer patients (94). Although there is no clinical data regarding FP-1039 for GC patients, it may be promising considering that FGF7 is possibly a critical player in TME of SGC.…”

Section: Monoclonal Antibodies Fgf Trapsmentioning

confidence: 98%

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer

et al. 2020

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Gastric cancer (GC) is the third leading cause among all cancer deaths globally. Although the treatment outcome of GC has improved, the survival of patients with GC at stages III and IV remains unsatisfactory. Among several types of GC, scirrhous type GC (SGC) shows highly aggressive growth and invasive activity, leading to frequent peritoneal metastasis. SGC is well known to accompany abundant stromal cells that compose the tumor microenvironment (TME) along with the produced extracellular matrix (ECM) and secreted factors. One of the main stromal components is cancer associated fibroblast (CAF). In the SGC microenvironment, CAFs are a source of various secreted factors, including fibroblast growth factors (FGFs), which mediate prominent tumor-stimulating activity. In turn, cancer cells also secrete numerous factors, which can activate and educate CAFs. Current findings suggest that cancer cells and stromal cells communicate interactively via the soluble factors, the ECM, and likely also by exosomes. In this review, we focus on the soluble factors mediating communication between cancer cells and CAFs in SGC, and consider how they are related to the modulation of TME and the high rate of peritoneal metastasis. At last, we discuss the perspectives on targeting these communication pathways for improved future treatment.

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Section: Monoclonal Antibodies Fgf Trapsmentioning

confidence: 98%

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer

et al. 2020

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“…showed that FP-1039 was well tolerated even in combination with chemotherapy. 49,50 As a result, CCA patients are expected to have even good tolerance to FP-1039; thus, studies on the effects of FP-1039 in CCA treatment should be arranged.…”

Section: Fgf/fgfr and Its Role In Tumorigenesismentioning

confidence: 99%

“… 47 , 48 The phase I dose-finding study of FP-1039 [ ClinicalTrials.gov identifier: NCT00687505] and the phase Ib study of FP-1039 in FGFR1-amplified NSCLC [ ClinicalTrials.gov identifier: NCT01868022] both showed that FP-1039 was well tolerated even in combination with chemotherapy. 49 , 50 As a result, CCA patients are expected to have even good tolerance to FP-1039; thus, studies on the effects of FP-1039 in CCA treatment should be arranged.…”

Section: Therapies Targeting Fgf/fgfr Signaling In Ccamentioning

confidence: 99%

Targeting the FGFR signaling pathway in cholangiocarcinoma: promise or delusion?

Wang

Xing

et al. 2020

Ther Adv Med Oncol

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Cholangiocarcinoma (CCA) is a refractory cancer with limited treatment options and poorly understood molecular mechanisms underlying tumor development. The most effective treatment is surgical resection; however, patients are highly prone to recurrence. Moreover, considering that most patients are diagnosed in advanced stages, treatment options are restricted to palliative care, which results in poor prognosis. Due to the limited effect of chemotherapy and radiotherapy, targeted therapy is becoming a hot topic in the field of biliary cancer treatment. The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway involves a variety of key biological processes for cell survival, differentiation, and metabolism. Next-generation sequencing data mining has shown that high levels of FGF/FGFR expression are associated with reduced overall survival (OS) in CAA, which indicates that the FGF/FGFR pathway may be an effective target for CAA treatment. This paper reviews the effect of FGF/FGFR signaling on CCA from onset to treatment and highlights the promise of FGF/FGFR signaling pathway inhibitors for targeting CCA.

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“…The most famous example could be Taxol (Figure 3) which is widely used to treat many types of cancers, such as breast cancer [61,62,63], ovarian cancer [64,65,66], lung cancer [67,68,69], cervical cancer [70,71,72], etc. Taxol and its semi-synthetic derivative cabazitaxel furthered interest in the study of oxetanes.…”

Section: Oxetanesmentioning

confidence: 99%

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

Harmalkar

Choi

et al. 2019

Molecules

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Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3–7 membered rings.

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An open-label phase IB study to evaluate GSK3052230 in combination with paclitaxel and carboplatin, or docetaxel, in FGFR1-amplified non-small cell lung cancer

Cited by 19 publications

References 26 publications

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer

Targeting the FGFR signaling pathway in cholangiocarcinoma: promise or delusion?

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

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