An Open-label Randomized Clinical Study to Compare the Effects of a Nutritional Supplement versus Vitamin E on Fibroscan Score in Nonalcoholic Steatohepatitis (NASH) Patients

Ashraf, Shahed; Alam, Jamshed; Sarkar, Jahangir; Khondaker, Faiz Ahmed; Farhana, Yusuf; Khan, Nazia

doi:10.13189/ujph.2018.060204

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…OOS has demonstrated its antitumoral activity in several clinical trials including hepatocellular carcinoma ( 24 ), melanoma ( 25 ), head and neck ( 26 ), prostate ( 27 ), cervical and endometrial cancer ( 28 ) among others ( 29 , 30 ), and can improve the quality of life of patients ( 3 ). On the other hand, VS is a nutritional supplement that has properties as immunomodulator and hepatoprotector ( 4 , 5 , 7 , 31 , 32 ) which have also been tested in a number of trials ( 31-33 ).…”

Section: Discussionmentioning

confidence: 99%

Ocoxin oral solution demonstrates antiviral properties in cellular models

2021

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Ocoxin Oral Solution (OOS) and Viusid (VS) are nutritional supplements that include several natural products which affect different cellular functions, such as proliferation or the redox status. In addition, some of their constituent components have been described to exert an antiviral effect. Considering this, it was hypothesized that treatment with OOS and VS could protect from viral infections. In order to evaluate the impact of OOS and VS on viral infection, lentivirus and retrovirus whose genomes coded for green fluorescent protein were used. In addition, and as a second approach to measure viral infection, a hemagglutinin-tagged form of the mitogen-activated protein kinase ERK5 was also inserted in the retroviral vector. Viral particles produced in 293T cells were used to infect HeLa cells in the presence or absence of OOS or VS. It was observed that VS had a minimal effect on the capacity of either lentivirus or retrovirus to infect HeLa cells. However, OOS significantly reduced the infection of HeLa cells with both of these viruses. The effect was dose-dependent, reaching a maximum at a 1:100 dilution of OOS. These results suggested that, in addition to its well-known antitumoral properties, OOS may also inhibit infection with viruses. This effect is relevant since patients receiving oncological therapies are more susceptible to viral infections, and nutritional supplements such as OOS may help in reducing the severity of these potential pathogenic infections.

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Section: Discussionmentioning

confidence: 99%

Ocoxin oral solution demonstrates antiviral properties in cellular models

2021

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Licorice and liver function in patients with primary liver disease: A systematic review and meta‐analysis of RCTs

Giangrandi,

Dinu,

Napoletano

et al. 2024

Phytotherapy Research

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Licorice (Glycyrrhiza spp.) has been a cornerstone of traditional Chinese and Japanese medicine. This systematic review and meta‐analysis aimed to evaluate the efficacy of licorice formulations, alone or in combination with other herbs, on liver function enzymes in patients with primary liver disease. We systematically searched MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library up to April 2024. Randomized controlled trials (RCTs) comparing the effects of Glycyrrhiza spp. preparations versus placebo or standard of care controls were included. Standard Cochrane methods were used to extract data and appraise eligible studies. A total of 15 RCTs, involving 1367 participants, were included in the analysis. The studies varied widely in geographical location, duration, and licorice preparations used. Licorice significantly reduced alanine aminotransferase (ALT) by 15.63 U/L (95% CI: −25.08, −6.18; p = 0.001) and aspartate aminotransferase (AST) by 7.37 U/L (95% CI: −13.13, −1.61; p = 0.01) compared to control groups. Subgroup analyses revealed that purified glycyrrhizic acid compounds were particularly effective, showing greater reductions in ALT and AST without significant heterogeneity. Although licorice treatment did not significantly impact gamma‐glutamyl transferase and total bilirubin (TBIL) levels overall, specific licorice‐herb preparations did show a notable reduction in TBIL. The safety profile of licorice was consistent with known side effects, predominantly mild and related to its mineralocorticoid effects. Despite heterogeneity and potential language bias, the findings suggest that licorice can enhance liver function. Further studies should standardize licorice preparations and explore its role in multifaceted herbal formulations to better understand its hepatoprotective mechanisms.

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An Open-label Randomized Clinical Study to Compare the Effects of a Nutritional Supplement versus Vitamin E on Fibroscan Score in Nonalcoholic Steatohepatitis (NASH) Patients

Cited by 2 publications

References 9 publications

Ocoxin oral solution demonstrates antiviral properties in cellular models

Ocoxin oral solution demonstrates antiviral properties in cellular models

Licorice and liver function in patients with primary liver disease: A systematic review and meta‐analysis of RCTs

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