Abstract:ObjectiveTo evaluate the efficacy and safety of leflunomide for the treatment of acute, symptomatic COVID-19.MethodsA single-center, open-label, randomized controlled trial was performed during an outbreak of SARS-CoV-2 Omicron variant in December 2022. Symptomatic patients within 5 days of COVID-19 onset were randomly allocated to receive 5 days of either symptomatic treatment with leflunomide or symptomatic treatment alone. The primary endpoint was time to sustained clinical recovery.ResultsFifty-seven parti… Show more
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