An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia

Dhurat, Rachita; Chitallia, Jill; May, Theodor W.; Jayaraaman, Ammani M.; Jithendriya, Madhukara; Anandan, Subbu; Vaidya, Pradyumna; Klenk, Adolf

doi:10.1159/000481141

Cited by 39 publications

(31 citation statements)

References 16 publications

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“…There is an increasing interest in alternative treatments that are a simple and cost‐effective with no adverse effects for patients unsatisfied with conventional therapy. Diverse formulations are developed to address this demand . Many hair growth promoters topical formulations are based on herbs and their active constituents .…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Anzai¹,

Pereira²,

Malaquias³

et al. 2020

Dermatologic Therapy

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Androgenetic alopecia (AGA) and telogen effluvium (TE) are common causes of hair loss, with limited options for treatment. The aim of this study was to determine the efficacy and safety of a new formulation kit (Pielus Anti‐hair loss lotion and shampoo) containing anti‐inflammatory and antioxidant agents in patients with TE and/or AGA. This was a prospective, single‐arm, open‐label study with 35 women and 10 men, median age of 44 years, with clinical diagnosis of TE and/or AGA. They used the combination of shampoo and lotion daily for 90 days. There was nonoccurrence of adverse events. Phototricogram showed increase in the average number of anagen hairs at T90 (P < .001). Scalp microphotography showed increase in total follicular units, total of hairs, and median hair per follicle unit at T90. There was an increase in diameter (P = .003) and in median maximum load and resistance to traction in T90 (P = .040). Combing and washing test demonstrated a decrease in the number of shed hairs before washing (P = .005), after washing (P = .01) and in total (P < .001). The use of shampoo+ lotion daily was safe and effective to attenuate hair loss in men and women with TE and/or AGA.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Anzai¹,

Pereira²,

Malaquias³

et al. 2020

Dermatologic Therapy

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“…Caffeine counteracts testosterone-enhanced TGF-2 protein expression in male HFs and reduces TGF-2 expression in female HFs, while it enhances intrafollicular IGF-1 protein expression in both sexes [80]. Accordingly, it enhances hair shaft elongation, prolongs anagen duration, and promotes the proliferation of hair matrix keratinocytes [81] (Table 4). In men affected by AGA, topical application of caffeine may be considered more effective than MXD 5% topical solution [82].…”

Section: Coffea Arabica Lmentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…Caffeine lotion (unknown concentration) has also been tested with similar results, including decrease in hairs released during the hair-pull test and positive treatment response in 75% of patients at 2 months and 83% at 4 months [21]. Comparison of 0.2% caffeine topical liquid to 5% topical minoxidil (MXD) demonstrated noninferiority (n = 210) with 10.59% improvement in anagen ratio compared to 11.68% using MXD (p = 0.574) [22].…”

Section: Caffeinementioning

confidence: 99%

“…Another topical solution containing 1% caffeine, 5% MXD, and 1.5% azelaic acid was more effective for hair regrowth and decreased shedding after 32 weeks of treatment compared to 5% MXD alone or placebo [24]. Topical caffeine shows potential as a CAM for hair loss; however, studies are limited by lack of quantitative, standardized evaluation [18,19,[21][22][23][24][25].…”

Section: Caffeinementioning

confidence: 99%

Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

Hosking

Juhász

Mesinkovska

2018

Skin Appendage Disord

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The treatment of alopecia is limited by a lack of therapies that induce and sustain disease remission. Given the negative psychosocial impact of hair loss, patients that do not see significant hair restoration with conventional therapies often turn to complementary and alternative medicine (CAM). Although there are a variety of CAM treatment options on the market for alopecia, only a few are backed by multiple randomized controlled trials. Further, these modalities are not regulated by the Food and Drug Administration and there is a lack of standardization of bioactive in gredients in over-the-counter vitamins, herbs, and supplements. In this article, we provide a comprehensive review of the efficacy, safety, and tolerability of CAM, including natural products and mind and body practices, in the treatment of hair loss. Overall, there is a need for additional studies investigating CAM for alopecia with more robust clinical design and standardized, quantitative outcomes.

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An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia

Cited by 39 publications

References 16 publications

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Efficacy and safety of a new formulation kit (shampoo + lotion) containing anti‐inflammatory and antioxidant agents to treat hair loss

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Complementary and Alternative Treatments for Alopecia: A Comprehensive Review

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