An Open-Label Study of Citalopram in Body Dysmorphic Disorder

Phillips, Katharine A.; Najjar, Fedra

doi:10.4088/jcp.v64n0615

Cited by 130 publications

(85 citation statements)

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“…Individuals with BDD had poor psychosocial functioning, consistent with previous studies (Hollander et al, 1999;Phillips, 2000;Phillips, 2006;Phillips & Najjar, 2003). In addition, prospectively assessed functioning remained stably poor over time.…”

Section: Discussionsupporting

confidence: 87%

“…SRI efficacy trials have consistently found that subjects treated with an SRI have significant improvement in psychosocial functioning (Hollander et al, 1999;Phillips, 2006;Phillips & Najjar, 2003;. In the present study, receipt of CBT did not predict better functioning.…”

Section: Discussioncontrasting

confidence: 52%

“…For example, on the SF-36 subscale that assesses role limitations due to emotional problems, BDD subjects' scores were 1.6 standard deviation units poorer than U.S. population norms; on the social functioning subscale, their scores were 2.2 standard deviation units poorer (Phillips, 2000). Similarly poor SF-36 scores were reported in two small open-label pharmacotherapy studies (Phillips, 2006;Phillips & Najjar, 2003). Mental health-related SF-36 subscale scores in all three studies were poorer than norms for clinical depression (Ware, 1993).…”

mentioning

confidence: 91%

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Functional impairment in body dysmorphic disorder: A prospective, follow-up study

Phillips

Quinn

Stout

2008

Journal of Psychiatric Research

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Cross sectional/retrospective studies indicate that individuals with body dysmorphic disorder (BDD) have markedly impaired psychosocial functioning. However, no study has prospectively examined functioning in BDD. In this study, which is to our knowledge the first prospective study of the course of BDD, psychosocial functioning was assessed at baseline and over 1 to 3 years (mean = 2.7 ± 0.9 years) of follow-up with the Global Assessment of Functioning Scale (GAF), Social and Occupational Functioning Scale (SOFAS), and LIFE-RIFT (Range of Impaired Functioning Tool). Psychosocial functioning was poor during the follow-up period. Functioning remained stably poor over time on the SOFAS and LIFE-RIFT, although there was a trend for a gradual and slight improvement on the GAF over time. The cumulative probability of attaining functional remission on the GAF (score >70 for at least 2 consecutive months) during the follow-up period was only 5.7%. On the SOFAS, the cumulative probability of attaining functional remission (score >70 for at least 2 consecutive months) was 10.6%. BDD severity significantly predicted functioning on the GAF (p=.0012), SOFAS (p=.0017), and LIFE-RIFT (p=.0015). A trend for a time-by-BDD severity interaction was found on the GAF (p=.033) but not the SOFAS or LIFE-RIFT. More delusional BDD symptoms also predicted poorer functioning on all measures, although this finding was no longer significant when controlling for BDD severity. Functioning was not predicted, however, by age, gender, BDD duration, or a personality disorder. In conclusion, psychosocial functioning was poor over time, and few subjects attained functional remission. Greater BDD severity predicted poorer functioning.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 52%

mentioning

confidence: 91%

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Functional impairment in body dysmorphic disorder: A prospective, follow-up study

Phillips

Quinn

Stout

2008

Journal of Psychiatric Research

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“…There are also preliminary findings that the serotonin agonist mCPP but not placebo causes exacerbation of preoccupations with perceived bodily defects in patients with BDD (Hollander & Wong, 1995). Other indirect evidence comes from several open and controlled treatment studies that demonstrated that high-dose SRIs (Perugi et al, 1996;Phillips, Albertini, & Rasmussen, 2002;Phillips, Dwight, & McElroy, 1998;Phillips & Najjar, 2003) but not desipramine (Hollander et al, 1999), a primarily noradrenergic medication, are effective for treating BDD. However, perturbations of the serotonergic system that exacerbate or alleviate BDD symptoms do not prove that abnormalities of the serotonergic system necessarily underlie the pathophysiology of BDD.…”

Section: Neurochemistry Of Bddmentioning

confidence: 99%

The pathophysiology of body dysmorphic disorder

2008

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Body dysmorphic disorder (BDD) is an often severe and disabling condition, affecting up to 2% of the population. Despite its prevalence and clinical significance, very little is known about the pathophysiology of BDD. However, clues to its possible neurobiological substrates and abnormalities in information processing are starting to emerge. This article reviews findings from genetic, brain lesion, neuroimaging, neuropsychological, and psychopharmacological studies that have allowed us to develop a tentative model of the functional neuroanatomy of BDD. There is likely a complex interplay of dysfunctions in several brain networks underlying the pathophysiology of BDD. A combination of dysfunctions in frontal-subcortical circuits, temporal, parietal, and limbic structures, and possibly involving hemispheric imbalances in information processing, may produce both the characteristic symptoms and neurocognitive deficits seen in BDD. An improved understanding of the pathophysiology of BDD will be crucial to guide the development of better treatments.

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“…Aufgrund der vorläufigen Hinweise auf die mögliche Effektivität von SSRI bei KDS [20][21][22][23] [26]. Zum anderen könnten die rapide Weiterentwicklung und die Verbreitung von medizinischen, insbesondere plastisch-chirurgischen Behandlungsmethoden den Bedarf an Korrekturen gesteigert haben [27,28].…”

Section: » Neben Individuellen Psychischen Und Biologischen Dispositiunclassified