An Open Labeled, Randomized, Parallel Arms, Clinical Trial to Evaluate Sedative Effect of Leaves of Beejapura (Citrus Medica Linn.) and Rhizome of Jatamansi (Nardostachys Grandiflora) in Anidra (Primary Insomnia)

Abstract

Primary insomnia is a major health issue with a bearing on the morbidity, health related quality of life. Pharmacologic treatment for insomnia has been shown to be associated with significant side effects; hence, it is need to search safe and effective remedies from natural sources. Powder of Beejapura (Citrus medica Linn) leaves with honey has been indicated to induce sleep in classical text of Ayurveda. Keeping this in view, open labelled, randomised parallel arm clinical trial was planned to evaluate the efficacy of the leaves powder of Citrus medica Linn. on primary insomnia in comparison to Jatamansi (rhizome of Nardostrachys grandiflora DC). Patients of primary insomnia belonging to age group of 20-70 years were diagnosed on the basis of diagnostic criteria given for insomnia in DSM -IV-TR. Total 66 patients were registered and randomly allocated in two arms, among them, total 62 completed the trials. Statistically, 30.6% overall effect was provided by Beejapura leaves, whereas 55.6% overall effect was provided by Jatamansi rhizome in the signs and symptoms of Primary insomnia. The difference between both therapies was statistically significant (p<0.001) wherein Jatamansi rhizome produced clinically better result in comparison to Beejapura leaves. Data indicates that Beejapura leaves improved only late sleep induction whereas Jatamansi rhizome provided better improvement in terms of late sleep induction and sleep maintenance.

Potential mechanisms of traditional Chinese medicine in treating insomnia: A network pharmacology, GEO validation, and molecular-docking study

“…[64] A randomized controlled trial demonstrated that GS played a crucial role in sleep induction and sleep maintenance for patients with insomnia. [65] We identified 54 bioactive ingredients of core herbs treating insomnia, including β-sitosterol, stigmasterol, cryptotanshinone, cavidine, and baicalein. β-Sitosterol is derived from BX, XKC, and BH; stigmasterol comes from BH and BX; canadine is found in YHS; cryptotanshinone is present in GS; cavidine is found in BX and YHS; baicalein is derived from BX and HH.…”

“…[ 64 ] A randomized controlled trial demonstrated that GS played a crucial role in sleep induction and sleep maintenance for patients with insomnia. [ 65 ]…”