In this paper, we consider the linear-quadratic timeinconsistent mean-field leader-follower Stackelberg stochastic differential game with an adapted open-loop information structure. Given a controlled linear stochastic differential equation (SDE), the quadratic objective functionals of the leader and the follower include conditional expectations of state and control (mean field) variables. In addition, the cost parameters could be general nonexponential discounting depending on the initial time. As stated in the existing literature, these two general settings of the objective functionals induce time inconsistency in the optimal solutions. Given an arbitrary control of the leader, we first obtain the follower's (time-consistent) equilibrium control and its state feedback representation in terms of the nonsymmetric coupled Riccati differential equations (RDEs) and the backward SDE. This provides the rational behavior of the follower, characterized by the forward-backward SDE (FBSDE). We then obtain the leader's explicit (time-consistent) equilibrium control and its state feedback representation in terms of the nonsymmetric coupled RDEs, where the constraint of the leader's problem is the FBSDE induced by the follower's rational behavior. With the solvability of the nonsymmetric coupled RDEs, the equilibrium controls of the leader and the follower constitute the time-consistent Stackelberg equilibrium of the paper. Finally, the numerical examples are provided to check the solvability of the nonsymmetric coupled RDEs of the leader and the follower.Index Terms-time-inconsistent stochastic control problem, equilibrium control, Stackelberg differential games, mean-field stochastic systems. 4 This implies that the magnitude of the stochastic noise is controlled by the leader and the follower, which can be viewed as multiplicative noise of the system [51], [52]. 5 As mentioned, an equilibrium control is time consistent; see Definition 2 or [3, Definition 4.1] and [26, Definition 2.1].