An open-source musculoskeletal model of the lumbar spine and lower limbs: a validation for movements of the lumbar spine

Favier, C; Finnegan, Mary E.; Quest, Rebecca A.; Honeyfield, Lesley; McGregor, Alison H.; Phillips, A.T.M.

doi:10.1080/10255842.2021.1886284

Cited by 23 publications

(30 citation statements)

References 59 publications

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“…Physiological loading and boundary conditions are essential to provide a realistic mechanical environment for finite element simulations (Bitsakos et al, 2005;Phillips et al, 2007;Speirs et al, 2007;Phillips, 2009). The combined multiscale modelling approach relies on a detailed musculoskeletal model with identical geometry to provide this mechanical environment (Favier et al, 2021). However, assumptions made for the musculoskeletal model will impact the finite element results (Wagner et al, 2010;Cronskaer et al, 2013;Zhu et al, FIGURE 11 | 3 mm mid-sagittal (XY plane) and through-processes transverse (XZ plane) slices of the converged models in the sedentary scenario, showing a map of which activity gives rise to the highest absolute maximum axial strain for the adaptation of the trabecular truss elements of the primary (A,C) and secondary (B,D) structures.…”

Section: Discussionmentioning

confidence: 99%

“…The load cases applied to the finite element model were obtained with a previously validated subject-specific musculoskeletal model of the lumbar spine and lower limbs (Favier et al, 2021 ). This musculoskeletal model is based on full-body high-resolution MRI scans of a healthy volunteer (26 yo, 175 cm , 67.8 kg ) with no history of spine pathologies.…”

Section: Methodsmentioning

confidence: 99%

“…It was developed in OpenSim 3.3 (Delp et al, 2007 ) and is available to download at https://simtk.org/projects/llsm/ . Full-body motion capture data were collected with the same healthy volunteer for eighteen activities following a previously developed protocol (Favier et al, 2021 ). The study was granted ethical approval by the NHS Health Research Authority (REC reference: 17/HRA/0465) and the Imperial College Research Ethics Committee (ICREC reference: 17IC3811), and the volunteer gave written informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…Base models of the five lumbar vertebrae were created from the MRI scans of the same healthy volunteer recruited to develop the musculoskeletal model (Favier et al, 2021 ). These base structural models were generated using the same approach as described in Phillips ( 2012 ), Phillips et al ( 2015 ), and Zaharie and Phillips ( 2018 ) and summarized here.…”

Section: Methodsmentioning

confidence: 99%

“…These base structural models were generated using the same approach as described in Phillips ( 2012 ), Phillips et al ( 2015 ), and Zaharie and Phillips ( 2018 ) and summarized here. The bone geometries were segmented in Mimics (Mimics Research 19.0, Materialise NV, Leuven, Belgium), reconstructed and exported as STL files following the protocol described in Favier et al ( 2021 ). The STL files were then imported in 3-matic (3-matic Research 11.0, Materialise NV, Leuven, Belgium) where the coordinate systems of the vertebrae were adjusted to match the joint definitions used in the musculoskeletal model.…”

Section: Methodsmentioning

confidence: 99%

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Maintaining Bone Health in the Lumbar Spine: Routine Activities Alone Are Not Enough

Favier

McGregor

Phillips

2021

Front. Bioeng. Biotechnol.

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Public health organisations typically recommend a minimum amount of moderate intensity activities such as walking or cycling for two and a half hours a week, combined with some more demanding physical activity on at least 2 days a week to maintain a healthy musculoskeletal condition. For populations at risk of bone loss in the lumbar spine, these guidelines are particularly relevant. However, an understanding of how these different activities are influential in maintaining vertebral bone health is lacking. A predictive structural finite element modelling approach using a strain-driven algorithm was developed to study mechanical stimulus and bone adaptation in the lumbar spine under various physiological loading conditions. These loading conditions were obtained with a previously developed full-body musculoskeletal model for a range of daily living activities representative of a healthy lifestyle. Activities of interest for the simulations include moderate intensity activities involving limited spine movements in all directions such as, walking, stair ascent and descent, sitting down and standing up, and more demanding activities with large spine movements during reaching and lifting tasks. For a combination of moderate and more demanding activities, the finite element model predicted a trabecular and cortical bone architecture representative of a healthy vertebra. When more demanding activities were removed from the simulations, areas at risk of bone degradation were observed at all lumbar levels in the anterior part of the vertebral body, the transverse processes and the spinous process. Moderate intensity activities alone were found to be insufficient in providing a mechanical stimulus to prevent bone degradation. More demanding physical activities are essential to maintain bone health in the lumbar spine.

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