An open source pharma roadmap

Balasegaram, Manica; Kolb, Peter; McKew, John C.; Menon, Jaykumar; Olliaro, Piero; Sablinski, Tomasz; Thomas, Zakir; Todd, Matthew H.; Torreele, Els; Wilbanks, John

doi:10.1371/journal.pmed.1002276

Cited by 29 publications

(29 citation statements)

References 29 publications

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“…Recognising the value of open source and open scholarship in accelerating innovation and research discovery (e.g., Woelfle et al, 2011;Balasegaram et al, 2017).…”

Section: Democratizationmentioning

confidence: 99%

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Foundations for Open Scholarship Strategy Development

Beamer¹,

Bosman²,

Brembs³

et al. 2019

Preprint

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This document aims to agree on a broad, international strategy for the implementation of open scholarship that meets the needs of different national and regional communities but works globally.Scholarly research can be idealised as an inspirational process for advancing our collective knowledge to the benefit of all humankind. However, current research practices often struggle with a range of tensions, in part due to the fact that this collective (or “commons”) ideal conflicts with the competitive system in which most scholars work, and in part because much of the infrastructure of the scholarly world is becoming largely digital. What is broadly termed as Open Scholarship is an attempt to realign modern research practices with this ideal. We do not propose a definition of Open Scholarship, but recognise that it is a holistic term that encompasses many disciplines, practices, and principles, sometimes also referred to as Open Science or Open Research. We choose the term Open Scholarship to be more inclusive of these other terms. When we refer to science in this document, we do so historically and use it as shorthand for more general scholarship.The purpose of this document is to provide a concise analysis of where the global Open Scholarship movement currently stands: what the common threads and strengths are, where the greatest opportunities and challenges lie, and how we can more effectively work together as a global community to recognise and address the top strategic priorities. This document was inspired by the Foundations for OER Strategy Development and work in the FORCE11 Scholarly Commons Working Group, and developed by an open contribution working group.Our hope is that this document will serve as a foundational resource for continuing discussions and initiatives about implementing effective strategies to help streamline the integration of Open Scholarship practices into a modern, digital research culture. Through this, we hope to extend the reach and impact of Open Scholarship into a global context, making sure that it is truly open for all. We also hope that this document will evolve as the conversations around Open Scholarship progress, and help to provide useful insight for both global co-ordination and local action. We believe this is a step forward in making Open Scholarship the norm.Ultimately, we expect the impact of widespread adoption of Open Scholarship to be diverse. We expect novel research practices to accelerate the pace of innovation, and therefore stimulate critical industries around the world. We could also expect to see an increase in public trust of science and scholarship, as transparency becomes more normative. As such, we expect interest in Open Scholarship to increase at multiple levels, due to its inherent influence on society and global economics.

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“…Recognising the value of open source and open scholarship in accelerating innovation and research discovery (e.g., Woelfle et al, 2011;Balasegaram et al, 2017).…”

Section: Democratizationmentioning

confidence: 99%

“…Overcoming the misconception that Open Scholarship is anti-commercial/demonstrating return on investment (e.g., Balasegaram et al, 2017;Hakoum et al, 2017).…”

Section: External Conditionsmentioning

confidence: 99%

Foundations for Open Scholarship Strategy Development

Beamer¹,

Bosman²,

Brembs³

et al. 2019

Preprint

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“…Projects need to generate and capture value (Chesbrough 2007). Open science projects are expanding their presence in the current innovation ecosystem, and may generate competitive scientific and economic benefits by minimizing transaction costs (licensing and legal fees) and formal requirements (licenses and negotiations) and facilitating knowledge dissemination and training (Allarakhia 2013;Balasegaram et al 2017;Shaw 2017). Their potentially increasing economic success has been key in justifying continued support from the public sector, as well as growing interest for members of the private sector to invest in the open science model.…”

Section: Sustainabilitymentioning

confidence: 99%

Open science precision medicine in Canada: Points to consider

Moreno

Ali‐Khan

Capps

et al. 2019

FACETS

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Open science can significantly influence the development and translational process of precision medicine in Canada. Precision medicine presents a unique opportunity to improve disease prevention and healthcare, as well as to reduce health-related expenditures. However, the development of precision medicine also brings about economic challenges, such as costly development, high failure rates, and reduced market size in comparison with the traditional blockbuster drug development model. Open science, characterized by principles of open data sharing, fast dissemination of knowledge, cumulative research, and cooperation, presents a unique opportunity to address these economic challenges while also promoting the public good. The Centre of Genomics and Policy at McGill University organized a stakeholders’ workshop in Montreal in March 2018. The workshop entitled “Could Open be the Yellow Brick Road to Precision Medicine?” provided a forum for stakeholders to share experiences and identify common objectives, challenges, and needs to be addressed to promote open science initiatives in precision medicine. The rich presentations and exchanges that took place during the meeting resulted in this consensus paper containing key considerations for open science precision medicine in Canada. Stakeholders would benefit from addressing these considerations as to promote a more coherent and dynamic open science ecosystem for precision medicine.

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“…Exclusive rights also waste opportunities; instead of using existing knowledge, research processes often need to circumvent what is known already to avoid litigation. In summary, by means of wasting resources and opportunities secrecy and exclusive rights raise discovery costs (Balasegaram et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

Open source pharma and its developmental potential | OSP e seu potencial de desenvolvimento

Arza

Sebastian

2018

Liinc Rev.

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A Open Source Pharma (OSP) é uma forma inovadora de realinhar a pesquisa farmacêutica com as demandas em saúde, em particular na busca de soluções para doenças infecciosas relacionadas à pobreza. A OSP significa a colaboração aberta, o acesso aberto a dados e outros resultados, e as licenças abertas para compartilhamento e distribuição de resultados de pesquisa. O artigo apresenta uma análise exploratória das práticas atuais e dos modelos de negócios adotados pela OSP a partir da revisão da literatura e de uma entrevista aprofundada com Matthew Todd, líder do projeto Open Source Malaria. Concluímos que a OSP pode se tornar uma alternativa de trabalho mais promissora do que a indústria farmacêutica tradicional, quando recebem apoio de políticas públicas, de modo que os seus benefícios possam se tornar plenamente visíveis.

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An open source pharma roadmap

Abstract: In an Essay, Matthew Todd and colleagues discuss an open source approach to drug development.

Cited by 29 publications

References 29 publications

Foundations for Open Scholarship Strategy Development

Foundations for Open Scholarship Strategy Development

Open science precision medicine in Canada: Points to consider

Open source pharma and its developmental potential | OSP e seu potencial de desenvolvimento

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