An open study of repetitive transcranial magnetic stimulation in treatment-resistant depression with Parkinson’s disease

Epstein, Charles M.; Evatt, Marian L.; Funk, Agnes P.; Girard-Siqueira, Lhys; Lupei, Nichole; Slaughter, Larisa; Athar, Saima; Green, Jonathan; McDonald, William M.; DeLong, Mahlon R.

doi:10.1016/j.clinph.2007.07.010

Cited by 82 publications

(55 citation statements)

References 38 publications

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“…In MDD associated with Parkinson's disease, several open and controlled studies have been published, showing consistent improvement of depressive symptoms as well as motor symptoms after prefrontal stimulation [132][133][134][135][136] . Two randomized controlled trials showed that the efficacy of rTMS is similar to fluoxetine in patients with this condition, but with less adverse events 133,135 .…”

Section: Parkinson's Diseasementioning

confidence: 99%

“…A recent study showed that ten to 15 sessions of rTMS applied on the left DLPFC at a frequency of 10Hz, and an intensity of 110% MT was associated with significant reduction of depressive symptoms by 30% and a remission rate of 10% as compared to placebo intervention. Mild and few adverse effects such as headache were reported [131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146][147][148][149] . Another advantage of the use of rTMS is the improvement in executive functions by rTMS 150,151 .…”

Section: Mdd In the Rehabilitation Settingmentioning

confidence: 99%

See 1 more Smart Citation

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Brunoni

Teng

Correa³

et al. 2010

Arq. Neuro-Psiquiatr.

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The use of neuromodulation as a treatment for major depressive disorder (MDD) has recently attracted renewed interest due to development of other non-pharmacological therapies besides electroconvulsive therapy (ECT) such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS). Method: We convened a working group of researchers to discuss the updates and key challenges of neuromodulation use for the treatment of MDD. results: The state-of-art of neuromodulation techniques was reviewed and discussed in four sections: [1] epidemiology and pathophysiology of MDD; [2] a comprehensive overview of the neuromodulation techniques; [3] using neuromodulation techniques in MDD associated with non-psychiatric conditions; [4] the main challenges of neuromodulation research and alternatives to overcome them. Discussion: ECT is the first-line treatment for severe depression. TMS and tDCS are strategies with a relative benign profile of side effects; however, while TMS effects are comparable to antidepressant drugs for treating MDD; further research is needed to establish the role of tDCS. DBS and VNS are invasive strategies with a possible role in treatment-resistant depression. In summary, MDD is a chronic and incapacitating condition with a high prevalence; therefore clinicians should consider all the treatment options including invasive and non-invasive neuromodulation approaches. Key words: comprehensive review, major depressive disorder, ECT, TMS, clinical guidelines.Estratégias de neuromodulação para o tratamento da depressão maior: desafios e recomendações de uma força-tarefa rEsuMo O uso de técnicas de neuromodulação para o tratamento do transtorno depressivo maior (TDM) tem despertado um renovado interesse nos últimos anos com o desenvolvimento de outras intervenções não-farmacólogicas além da eletroconvulsoterapia (ECT), como a estimulação magnética transcraniana (EMT), a estimulação transcraniana por corrente continua (ETCC), a estimulação cerebral profunda (DBS) e a estimulação de nervo vago (VNS). Método: Nós organizamos um grupo de trabalho com vários pesquisadores para discutir os avanços recentes e os principais desafios para o uso da neuromodulação no tratamento os principais desafios da pesquisa na neuromodulação e alternativas para superá-los. Discussão: ECT é o tratamento de primeira linha para depressão grave. EMT e ETCC são estratégias com um perfil benigno de efeitos adversos; contudo, enquanto os efeitos da EMT são comparáveis ao das drogas antidepressivas para o tratamento da TDM, a eficácia da ETCC ainda precisa ser estabelecida por mais pesquisas clínicas. DBS e VNS são intervenções invasivas com um papel possível para a depressão refratária. Em resumo, TDM é uma condição crônica, incapacitante e de alta prevalência; portanto na prática clínica todas as opções de tratamento possíveis, incluindo as farmacológicas e não-farmacológicas, devem ser consideradas. Palavras-chave: artigo de revisão, tra...

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Section: Parkinson's Diseasementioning

confidence: 99%

Section: Mdd In the Rehabilitation Settingmentioning

confidence: 99%

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Brunoni

Teng

Correa³

et al. 2010

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…[71][72][73][74][75][76][77][78][79] A recent meta-analysis of RCTs for the use of rTMS for the treatment of depressive symptoms in PD found rTMS to be superior to sham treatment in reducing depressive symptoms in PD, and to have similar efficacy as SSRIs, with the possible benefit of simultaneous improvement in motor symptoms. 80 Another meta-analysis found the effect of rTMS on depression in PD to be nonsignificant, based on the two existing RCTs.…”

Section: Alternative Treatmentsmentioning

confidence: 99%

Prevalence, impact, and management of depression and anxiety in patients with Parkinson’s disease

Renfroe

Turner²,

Hinson³

2016

JPRLS

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“…rTMS treatment in PD generally aims at improving motor symptoms, such as LIDs, bradykinesias and freezing of gait (FOG), though some studies also focused on non-motor symptoms, including depression and apathy [21], speech and voice [22,23] and cognitive functions [24].…”

Section: Rtms Rationale In Parkinson's Diseasementioning

confidence: 99%

Transcranial Magnetic Stimulation Treatment for Motor Symptoms in ParkinsonÃ¢ÂÂs Disease: A Review of Two Decades of Studies

Pallanti¹,

Marras²

2015

J Alzheimers Dis Parkinsonism

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In the last two decades, repetitive Transcranial Magnetic Stimulation (rTMS) has been increasingly employed in Parkinson's disease (PD) to enhance and restore motor function. Different cortical regions have been investigated as treatment targets (i.e. primary motor cortex, dorsolateral prefrontal cortex and supplementary motor area) and stimulation parameters (frequency, intensity, number of pulses) showed high heterogeneity between studies. Herein we review 40 studies, both open-label and randomized controlled trials: mixed results have been yielded regarding the effectiveness of rTMS treatment for motor symptoms in PD, due to the high variability of employed protocols, sham procedures and target regions. Although overall results seem to support the notion of potential beneficial effects of rTMS in PD, further research is needed to identify the optimal treatment parameters and to evaluate the potential conjunct use of rTMS in patients with deep brain stimulation (DBS) implants.

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An open study of repetitive transcranial magnetic stimulation in treatment-resistant depression with Parkinson’s disease

Abstract: TMS may be beneficial for depressed PD patients in multiple functional domains.

Cited by 82 publications

References 38 publications

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Prevalence, impact, and management of depression and anxiety in patients with Parkinson’s disease

Transcranial Magnetic Stimulation Treatment for Motor Symptoms in ParkinsonÃ¢ÂÂs Disease: A Review of Two Decades of Studies

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An open study of repetitive transcranial magnetic stimulation in treatment-resistant depression with Parkinson’s disease

Abstract: TMS may be beneficial for depressed PD patients in multiple functional domains.

Cited by 82 publications

References 38 publications

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Prevalence, impact, and management of depression and anxiety in patients with Parkinson&rsquo;s disease

Transcranial Magnetic Stimulation Treatment for Motor Symptoms in ParkinsonÃ¢ÂÂs Disease: A Review of Two Decades of Studies

Contact Info

Product

Resources

About

Prevalence, impact, and management of depression and anxiety in patients with Parkinson’s disease

Transcranial Magnetic Stimulation Treatment for Motor Symptoms in ParkinsonÃ¢ÂÂs Disease: A Review of Two Decades of Studies