International Journal of Cardiology

2018

DOI: 10.1016/j.ijcard.2018.03.117

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An operational definition of SHATS (Systemic Hemodynamic Atherosclerotic Syndrome): Role of arterial stiffness and blood pressure variability in elderly hypertensive subjects

¹

,

Valentina Rovella

²

,

Danilo Alunni Fegatelli³

et al.

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Relationship Among Arterial Stiffness Hiv Infection and Haart1

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Cited by 43 publications

(28 citation statements)

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“…Against the backdrop of aging society, enormous population countries especially for China are besetting by high prevalence of massive chronic diseases such as obesity 24 , diabetes 25 and et al, which bring about heavy burden to the patients, households and society. Among these non-communicable chronic diseases, metabolic syndrome is a significant issue because it can be as a significant determinant of arterial aging, chronic kidney disease and multiple organ damage 26 – 29 . MetS was investigated in our study by downloading data from CHARLS, a data library with high quality, nationally representative datasets collecting from the aged across China.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and associated factors of metabolic syndrome in Chinese aging population

Ge¹,

Yang²,

Li³

et al. 2020

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Metabolic syndrome (MetS) is hitting high notes in the aging society in China. However, the prevalence and associated factors in Chinese aging population lack clarity to some extent. In the present study, we projected to inquire into the prevalence of MetS and its associated factors by analyzing datasets downloaded from the China Health and Retirement Longitudinal Study (CHARLS). Data comprising age, gender, socioeconomic status, lifestyle and health behaviors as well as blood biomarkers were subjected to descriptive statistics followed by univariate logistic regression and multivariate logistic regression. The overall prevalence of MetS was 33.38% (95% CI 32.42–34.34%). With age augments, prevalence increased during 40–70 years, while declined in participants aged 70 years above. Females had 2.94 times of risks (95% CI 2.55–3.39, P < 0.001). Marital status and alcohol consumption contributed nothing to the suffering of MetS. Participants with GDP per capita > 10,000 RMB and a non-agricultural hukou sustained higher risks than other participants (P < 0.05). Participants under education of middle school suffered 1.16 times of risks than other level of education (95% CI 1.01–1.34, P < 0.05). Smokers, participants with high low-density lipoprotein (LDL) or hyperuricemia or high glycosylated hemoglobin HbA1c sustained increased risks (P < 0.05). In Chinese aging population, with the augment of age, the prevalence ascended in men, while descended in women and was interfered by socioeconomic status, lifestyle and health behaviors as well as blood biomarkers, but not marital status and alcohol consumption.

“…Against the backdrop of aging society, enormous population countries especially for China are besetting by high prevalence of massive chronic diseases such as obesity 24 , diabetes 25 and et al, which bring about heavy burden to the patients, households and society. Among these non-communicable chronic diseases, metabolic syndrome is a significant issue because it can be as a significant determinant of arterial aging, chronic kidney disease and multiple organ damage 26 – 29 . MetS was investigated in our study by downloading data from CHARLS, a data library with high quality, nationally representative datasets collecting from the aged across China.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and associated factors of metabolic syndrome in Chinese aging population

Ge¹,

Yang²,

Li³

et al. 2020

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is hitting high notes in the aging society in China. However, the prevalence and associated factors in Chinese aging population lack clarity to some extent. In the present study, we projected to inquire into the prevalence of MetS and its associated factors by analyzing datasets downloaded from the China Health and Retirement Longitudinal Study (CHARLS). Data comprising age, gender, socioeconomic status, lifestyle and health behaviors as well as blood biomarkers were subjected to descriptive statistics followed by univariate logistic regression and multivariate logistic regression. The overall prevalence of MetS was 33.38% (95% CI 32.42–34.34%). With age augments, prevalence increased during 40–70 years, while declined in participants aged 70 years above. Females had 2.94 times of risks (95% CI 2.55–3.39, P < 0.001). Marital status and alcohol consumption contributed nothing to the suffering of MetS. Participants with GDP per capita > 10,000 RMB and a non-agricultural hukou sustained higher risks than other participants (P < 0.05). Participants under education of middle school suffered 1.16 times of risks than other level of education (95% CI 1.01–1.34, P < 0.05). Smokers, participants with high low-density lipoprotein (LDL) or hyperuricemia or high glycosylated hemoglobin HbA1c sustained increased risks (P < 0.05). In Chinese aging population, with the augment of age, the prevalence ascended in men, while descended in women and was interfered by socioeconomic status, lifestyle and health behaviors as well as blood biomarkers, but not marital status and alcohol consumption.

“…Target organ damage and clinical outcomes have also been correlated with hemodynamic variables, including BP variability and cerebrovascular reactivity. Taking them into account could provide a more exhaustive assessment of the detrimental effects of altered BP and allow to explore potential differences across the clinical phenotypes 26‐28 . The second point is that the difference with the normotensives might be an effect of the classification.…”

Section: Discussionmentioning

confidence: 99%

Masked and white coat hypertension, the double trouble of large arteries: A systematic review and meta‐analysis

¹

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²

,

³

et al. 2020

J of Clinical Hypertension

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Registration number (DOI): Available in https://osf.io/974gb/, https://doi.Abstract Arterial damage of large arteries, addressed as c-f PWV, is recognized as independent predictor for future cardiovascular disease. The aim of this study was to systematically investigate the association of the four hypertension phenotypes with carotidfemoral pulse wave velocity (c-f PWV), in untreated patients. PubMed and Cochrane Library were searched to identify studies comparing c-f PWV levels between normotensives, sustained hypertensives, white-coat hypertensives (WCH), and masked hypertensives (MH). Meta-analysis was performed to compare the difference c-f PWV levels between these groups. Newcastle-Ottawa quality assessment scale for crosssectional studies was used to assess study quality. MH and WCH patients had significantly increased c-f PWV values compared to the normotensive groups (d = 0.96 m/s, 95% CI: 0.49-1.42; I2 = 85%, P < .01 for MH and d = 0.85 m/s, 95% CI: 0.48-1.22; I2 = 89%, for WCH). Moreover, the sustained hypertensive population was found to have significantly increased values of c-f PWV compared to MH (d = −0.70 m/s, 95% CI: −0.87 to −0.54; I2 = 12%, P = .33) but not compared to WCH population (d = −0.75 m/s, 95% CI: −1.52-0.02; I 2 = 96%,). Finally, there was no significant difference between MH and WCH population (d = 0.06 m/s, 95% CI: −1.04 to 1.15; I 2 = 96%,). MH and WCH population may have increased values of c-f PWV compared to the normotensive group. These results demonstrate that these phenotypes are not clinically innocent, in the untreated population.

“…Studies have shown that increased arterial stiffness in combination with hypotension may impair cognitive function in the elderly [ 29 ]. As pointed out by Scuteri, there may exist a so called Systemic Hemodynamic Atherosclerotic Syndrome (SHATS), involving a multitude of target organ damage related to vascular changes [ 30 ]. Furthermore, in the present Malmö cohort, correlations have been identified both between glucose levels and arterial stiffness [ 19 ] and between arterial stiffness and cognitive performance [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Pre-diabetes and diabetes are independently associated with adverse cognitive test results: a cross-sectional, population-based study

¹

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²

,

³

et al. 2018

BMC Endocr Disord

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BackgroundDiabetes is a risk factor for cognitive impairment, but whether there is also a link between pre-diabetes and cognitive dysfunction is not yet fully established. The aim of this observational study was to investigate associations between pre-diabetes/diabetes and cognitive test results, and also between glucose levels measured during the Oral Glucose Tolerance Test (OGTT) and cognitive outcomes.MethodsDuring 2007–2012, in all 2994 people (mean age 72 years), residing in Malmö, Sweden, underwent a clinical examination including the OGTT, cardiovascular measurements including carotid-femoral pulse wave velocity (c-f PWV) and two cognitive tests, the Mini Mental State Examination (MMSE), measuring global cognitive function, and A Quick Test of Cognitive Speed (AQT), measuring processing speed and executive functioning. Regression analyses were performed to investigate associations between: (a) categories of normal or impaired glucose metabolism, and (b) OGTT measurements, respectively, as exposure variables and cognitive test results as outcomes. Adjustments were made for demographics, lifestyle factors and cardiovascular risk factors.ResultsParticipants with pre-diabetes and diabetes scored slightly worse cognitive test results compared to the control group. Results of participants with a long disease duration of diabetes since the baseline examination 13 years earlier were poorer (mean AQT test time 17.8 s slower than controls, p < 0.001). Linear associations were found between fasting and 2-h glucose and cognitive outcomes in the whole population, but also in a sub-analysis including only individuals without diabetes (for 2-h glucose and MMSE results: B = − 2.961, p = 0.005). Associations were stronger for older or less physically active individuals. When adjusting for cardiovascular risk factors, most correlations were non-significant.ConclusionsPre-diabetes and diabetes are associated with minor deficits in global cognitive function, processing speed and executive functioning. Long-standing diabetes is associated with bigger deficits. There appears to be a continuous inverse correlation between glucose levels and cognitive test results, also for people without diabetes. Associations are stronger in older and less physically active individuals. Cardiovascular factors are important mediating factors in the pathway between diabetes and cognitive dysfunction.Electronic supplementary materialThe online version of this article (10.1186/s12902-018-0318-3) contains supplementary material, which is available to authorized users.

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