In this paper, we extend the operational matrix method to solve the tempered fractional differential equation, via shifted Legendre polynomial. Although the operational matrix method is widely used in solving various fractional calculus problems, it is yet to apply in solving fractional differential equations defined in the tempered fractional derivatives. We first derive the analytical expression for tempered fractional derivative for
x
p
, hence, using it to derive the new operational matrix of fractional derivative. By using a few terms of shifted Legendre polynomial and via collocation scheme, we were able to obtain a good approximation for the solution of the multiorder tempered fractional differential equation. We illustrate it using some numerical examples.