An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative, anti-inflammatory and anti-apoptosis activities

Zhang, Huan; Kang, Jun; Guo, Wu-Yan; Wang, Fu-jie; Guo, Mengjiao; Feng, Shijian; Zhou, Wuai; Li, Jinnan; T.Tahir, Ayesha; Wang, Shaoshan; Du, Xinjun; Zhao, Hui; Zhu, Hong; Zhang, Bo

doi:10.1016/j.chmed.2022.08.003

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…Meanwhile, mitochondria are involved in the regulation of intracellular Ca 2+ homeostasis, which leads to mitochondrial depolarization, which ultimately exacerbates oxidative stress-induced apoptosis . Caspase cascade and Bax family members are key to apoptosis signaling. , Our results showed that PD pretreatment inhibited the abnormal accumulation of ROS, prevented the loss of intracellular MMP, and blocked Ca 2+ inward flow. Moreover, PD treatment increased expression of the antiapoptotic protein Bcl-2 by controlling Bax translocated to the outer mitochondrial membrane, blocked cytochrome c release, and inhibited caspase-9 activation and downstream protein caspase-3 initiation.…”

Section: Discussionmentioning

confidence: 60%

Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway

Lu,

Xie,

et al. 2024

J. Agric. Food Chem.

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The aim of this study was to investigate the ameliorative effect of platycodin D (PD) on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and its potential molecular mechanisms of action in vivo and in vitro. Materials and methods: An animal model of cognitive impairment in T2DM was established using a single intraperitoneal injection of streptozotocin (100 mg/kg) after 8 weeks of feeding a high-fat diet to C57BL/6 mice. In vitro, immunofluorescence staining and Western blot were employed to analyze the effects of PD on glucose-induced neurotoxicity in mouse hippocampal neuronal cells (HT22). Results: PD (2.5 mg/kg) treatment for 4 weeks significantly suppressed the rise in fasting blood glucose in T2DM mice, improved insulin secretion deficiency, and reversed abnormalities in serum triglyceride, cholesterol, low-density lipoprotein, and high-density lipoprotein levels. Meanwhile, PD ameliorated choline dysfunction in T2DM mice and inhibited the production of oxidative stress and apoptosis-related proteins of the caspase family. Notably, PD dose-dependently prevents the loss of mitochondrial membrane potential, promotes phosphorylation of phosphatidylinositol 3 kinase and protein kinase B (Akt) in vitro, activates glycogen synthase kinase 3β (GSK3β) expression at the Ser9 site, and inhibits Tau protein hyperphosphorylation. Conclusions: These findings clearly indicated that PD could alleviate the neurological damage caused by T2DM, and the phosphorylation of Akt at Ser473 may be the key to its effect.

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Section: Discussionmentioning

confidence: 60%

Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway

Lu,

Xie,

et al. 2024

J. Agric. Food Chem.

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“…In vivo, MDA is the final product of oxidation reaction of free radicals. It contains relatively high cytotoxicity, which is easy to cause the destruction and dysfunction of macromolecular structures such as proteins in cells, resulting in oxidative damage of the body [ 28 , 29 ]. An antioxidant metalloenzyme existing in SOD organism, it can catalyze superoxide anion radical disproportionation, and plays a crucial role in the balance between oxidation and antioxidant in the body.…”

Section: Discussionmentioning

confidence: 99%

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium

Du,

Lu,

Xiao

et al. 2024

PLoS ONE

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Purpose This study aims to investigate the protective mechanism of dihydromyricetin PLGA nanoparticles (DMY-PLGA NPs) against myocardial ischemia-reperfusion injury (MIRI) in vitro and the improvement of oral bioavailability in vivo. Methods DMY-PLGA NPs was prepared and characterized by emulsifying solvent volatilization, and the oxidative stress model of rat H9c2 cardiomyocyte induced by H2O2 was established. After administration, cell survival rate, lactate dehydrogenase (LDH), malondialdehyde (MDA) and superoxide dismutase (SOD) were detected, and the expressions of PGC1α and PPARα were detected by western blot (WB). At the same time, the pharmacokinetics in rats were studied to explore the improvement of bioavailability. Results DMY-PLGA NPs can significantly increase cell survival rate, decrease LDH and MDA content, increase SOD content and PGC1α、PPARα protein expression. Compared with DMY, the peak time of DMY-PLGA NPs was extended (P<0.1), and the bioavailability was increased by 2.04 times. Conclusion DMY-PLGA NPs has a significant protective effect on H9c2 cardiomyocytes, which promotes the absorption of DMY and effectively improves bioavailability.

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“…This indicated that these CHM extracts have beneficial action for the alleviation of skin aging. It has been reported that glycyrrhizin, a natural extract from the licorice roots, is generally considered to offer protection against cellular senescence (Zhang et al, 2022). Matrix metalloproteinases (MMPs) are known to contribute to the degradation of collagen during ultraviolet irradiation (Yamada et al, 2021).…”

Section: Dong Et Almentioning

confidence: 99%

A novel combination against skin aging via promoting the synthesis of biological collagen

Dong,

Zhang,

Guo

et al. 2024

Journal of Food Bioactives

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Supplementing collagen is considered to contribute to delaying skin aging. In this work, we developed a novel combination for improving skin aging by stimulating the biosynthesis of collagen. By screening a library of Chinese herbal medicines (CHM), we found that Angelicae Dahuricae Radix (Baizhi), Lilii bulbus (Baihe), Glycyrrhizae radix et rhizoma (Gancao), and Jujubae fructus (Dazao) substantially increased the mRNA expression levels of type I collagen, suggesting their potential anti-skin-aging activity. To keep the structural integrity of collagen, prolyl 4-hydroxylase (P4H), a key enzyme in collagen synthesis, was recombinantly expressed in Escherichia coli. In addition, the transfersome with added P-4H was prepared to improve the transdermal absorption of combination. Vitamin C (VC), the substrate required for the activity of P4H, was also incorporated into the combination. Eventually, an optimal combination, consisting of Baizhi, Baihe, Gancao, P4H transfersome and VC, was obtained by a series of combination experiments. Based on traditional CHM and modern biological agents, we developed a novel combination against skin aging by promoting the synthesis of collagen. Collectively, the combination show the high potential of application to delay skin aging

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An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative, anti-inflammatory and anti-apoptosis activities

Cited by 7 publications

References 32 publications

Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway

Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium

A novel combination against skin aging via promoting the synthesis of biological collagen

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