“…Optimization of CRISPR/Cas9 technologies for zebrafish continues apace, with recent success in high‐efficiency targeted integration through homology‐directed repair using DNA or single‐stranded oligonucleotide templates (Prykhozhij et al, 2018; Wierson et al, 2020) or by direct base editing (see, for example, Rosello et al, 2021; Zhao, Shang, Ying, Cheng, & Zhou, 2020). Such approaches, as already exemplified by targeted disruption of the zebrafish Adgrg6 Ca 2+ ‐binding site (Leon et al, 2020), can be used to introduce specific human disease mutations into the zebrafish gene or to create a humanized Adgrg6 gene in zebrafish, which will provide a valuable resource for ADGRG6 disease modeling and drug validation.…”