An Optimum Animal Model for Neonatal Thoracoscopy

Jones, Vanessa; Wood, James G.; Godfrey, Craig; Cohen, Richard. D.

doi:10.1089/lap.2007.0224

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…In accordance with our hypothesis, the key finding of this experimental animal study was a significantly higher decrease in the individual CI after single-lung ventilation with carbon dioxide insufflation in comparison with single-lung ventilation alone, even though MAP remained within the physiological range. The experimental study design was chosen to facilitate invasive hemodynamic measurements under standardized conditions in an approved pediatric animal model (10), which is also applicable for ventilatory and thoracoscopic interventions (9,12). During the past decade, the use of VATS has increased in both adults and children, and recent advances in surgical technique and instrumentation have facilitated the use of VATS in infants and even premature infants (2,4,5,13).…”

Section: Discussionmentioning

confidence: 99%

Single‐lung ventilation with carbon dioxide hemipneumothorax: hemodynamic and respiratory effects in piglets

Witt

Osthaus

Schröder

et al. 2011

Pediatric Anesthesia

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Section: Discussionmentioning

confidence: 99%

Single‐lung ventilation with carbon dioxide hemipneumothorax: hemodynamic and respiratory effects in piglets

Witt

Osthaus

Schröder

et al. 2011

Pediatric Anesthesia

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“…To validate the quality of our method, we describe here experiments performed with this measurement protocol using a neonatal piglet model. Piglets have been chosen as animal models in many studies (Aquilina et al 2007, Xu et al 2007, Jones et al 2008, Puiman and Stoll 2008, Wanjun et al 2008, Xu et al 2010, Aquilina et al 2012 because of the anatomical, physiological, immunological and metabolic similarities between piglets and human neonates.…”

Section: Introductionmentioning

confidence: 99%

In vivoquantification of intraventricular hemorrhage in a neonatal piglet model using an EEG-layout based electrical impedance tomography array

et al. 2016

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Intraventricular hemorrhage (IVH) is a common occurrence in the days immediately after premature birth. It has been correlated with outcomes such as periventricular leukomalacia (PVL), cerebral palsy and developmental delay. The causes and evolution of IVH are unclear; it has been associated with fluctuations in blood pressure, damage to the subventricular zone and seizures. At present, ultrasound is the most commonly used method for detection of IVH, but is used retrospectively. Without the presence of adequate therapies to avert IVH, the use of a continuous monitoring technique may be somewhat moot. While treatments to mitigate the damage caused by IVH are still under development, the principal benefit of a continuous monitoring technique will be in investigations into the etiology of IVH, and its associations with periventricular injury and blood pressure fluctuations. Electrical impedance tomography (EIT) is potentially of use in this context as accumulating blood displaces higher conductivity cerebrospinal fluid (CSF) in the ventricles. We devised an electrode array and EIT measurement strategy that performed well in detection of simulated ventricular blood in computer models and phantom studies. In this study we describe results of pilot in vivo experiments on neonatal piglets, and show that EIT has high sensitivity and specificity to small quantities of blood (<1 ml) introduced into the ventricle. EIT images were processed to an index representing the quantity of accumulated blood (the ‘quantity index’, QI). We found that QI values were linearly related to fluid quantity, and that the slope of the curve was consistent between measurements on different subjects. Linear discriminant analysis showed a false positive rate of 0%, and receiver operator characteristic analysis found area under curve values greater than 0.98 to administered volumes between 0.5, and 2.0 ml. We believe our study indicates that this method may be well suited to quantitative monitoring of IVH in newborns, simultaneously or interleaved with electroencephalograph assessments.

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Porcine Models for Pediatric Minimally Invasive Surgical Training—A Template for the Future

Bidarkar

Deshpande²,

Kaur³

et al. 2012

Journal of Laparoendoscopic & Advanced Surgical Techniques

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Pediatric minimally invasive surgery is a rapidly developing field with a steep learning curve for each new procedure that is developed and integrated into practice. The European consensus is that the training across the learning curve should not be on the patients. Simulation is a widely accepted methodology to shorten the learning curve. Training on animal models is an advanced form of simulation. This helps to reduce morbidity and the costs of patient care. This article describes our 3 years of experience in the development of animal models for training in pediatric minimally invasive surgery.

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An Optimum Animal Model for Neonatal Thoracoscopy

Abstract: Our findings suggest that the piglet may be the optimum animal model for replicating neonatal thoracoscopy. The fragility of the rabbit, coupled with a limited intrathoracic working space, limits its use for thoracoscopy.

Cited by 4 publications

References 21 publications

Single‐lung ventilation with carbon dioxide hemipneumothorax: hemodynamic and respiratory effects in piglets

Single‐lung ventilation with carbon dioxide hemipneumothorax: hemodynamic and respiratory effects in piglets

In vivoquantification of intraventricular hemorrhage in a neonatal piglet model using an EEG-layout based electrical impedance tomography array

Porcine Models for Pediatric Minimally Invasive Surgical Training—A Template for the Future

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