An optofluidic “tweeze-and-drag” cell stretcher in a microfluidic channel

Yao, Zhanshi; Kwan, Ching Chi; Poon, Andrew W.

doi:10.1039/c9lc01026b

Cited by 38 publications

(27 citation statements)

References 54 publications

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“…utilized the combined effect of optical gradient force and fluidic drag force to realize cell stretching test in a continuous flow mode (Figure 3A). [ 92 ] Only one laser beam is required, which also eliminates the waveguide alignment requirement of the dual‐beam cell stretching system.…”

Section: Optofluidic Cell Analysis For Biodiagnostic Applicationsmentioning

confidence: 99%

Emerging optofluidic technologies for biodiagnostic applications

Dai

et al. 2021

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The unprecedented global COVID‐19 pandemic strongly argues the critical need for innovative diagnostic tools meeting the requirement of test speed, accuracy, and throughput. Owing to the integration of optics and microfluidics technologies, optofluidic technology enables highly precise flow manipulation and highly sensitive signal detection at the microscale, thus offering the promising potential for developing biodiagnostic applications. Research toward this direction is fast growing into an emerging area. In this paper, we give an overview of emerging optofluidic technologies for biodiagnostic applications with the focus on three common types of biomarkers: nucleic acid, protein, and cell. We conclude by discussing the challenges, opportunities, and future perspectives of this field.

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Section: Optofluidic Cell Analysis For Biodiagnostic Applicationsmentioning

confidence: 99%

Emerging optofluidic technologies for biodiagnostic applications

Dai

et al. 2021

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“…When addressing the mechanical properties of cells without the impact of cell adhesion, improved cell deformation/stretching biophysical techniques can be used, compromising an optical cell stretcher (Guck et al, 2005 ; Mierke et al, 2017 , 2020 ; Mierke, 2019b ) and microfluidics-based cell stretcher that represents a channel confinement for directional flowing or migrating cells (Huang et al, 2020 ; Yao et al, 2020 ).…”

Section: Development Establishment and Advancement Of Biophysical Techniquesmentioning

confidence: 99%

The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

Mierke

2021

Front. Cell Dev. Biol.

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“…[ 49,50 ] For biomedical‐related studies, it offers a key route to break new ground on multi‐functional “lab‐on‐a‐chip” systems with a small footprint, streamlined protocol, low required sample volume, and ideally high throughput. [ 51–55 ]…”

Section: Silicon Photonics For Label‐free Biosensingmentioning

confidence: 99%

“…[49,50] For biomedical-related studies, it offers a key route to break new ground on multi-functional "lab-on-a-chip" systems with a small footprint, streamlined protocol, low required sample volume, and ideally high throughput. [51][52][53][54][55] Various straightforward and convenient methods have been developed for integrating silicon-based materials with microfluidic components. [56] Polydimethylsiloxane (PDMS) as a low-cost, easy-to-use, optically transparent and biocompatible material is popular in the field of micro/nanofluidics with the capability of building complex 3D microfluidic circuits.…”

Section: Optofluidic Integrations For Silicon-based Biosensorsmentioning

confidence: 99%

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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An optofluidic “tweeze-and-drag” cell stretcher in a microfluidic channel

Abstract: An optofluidic cell stretcher using a periodically chopped optical tweezer and a microfluidic flow for non-contact, continuous cell mechanical characterization.

Cited by 38 publications

References 54 publications

Emerging optofluidic technologies for biodiagnostic applications

Emerging optofluidic technologies for biodiagnostic applications

The Pertinent Role of Cell and Matrix Mechanics in Cell Adhesion and Migration

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

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