An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study

Leppla, Lynn; Geest, Sabina De; Fierz, Katharina; Deschler-Baier, Barbara; Koller, Antje

doi:10.1007/s00520-015-2843-1

Cited by 25 publications

(21 citation statements)

References 41 publications

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“…Self-management education should include teaching objectives that excel in making the patient able to handle the situations inherent in their diagnosis, treatment and rehabilitation (6) . According to the intended learning objectives such as informing, knowing, generating skills and attitudes, single or combined strategies should be chosen, with the latter showing better results such as associations between verbal instructions, demonstrations and simulations, written materials (booklets/ leaflets), content through videos, and face-to-face multiprofessional consultations or by phone or website (4)(5)(6) .…”

Section: Introductionmentioning

confidence: 99%

Quality of life, anxiety and depression in head and neck cancer patients: a randomized clinical trial

Hortense

Bergerot

Domenico

2020

Rev. esc. enferm. USP

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OBJECTIVE To evaluate an educational program based on the principles of self-management with a conventional educational program through quality of life, anxiety and depression instruments within 12 months of starting cancer treatment. METHOD An experimental, randomized, controlled study conducted with head and neck cancer patients treated at a university hospital in the city of São Paulo, Brazil. Patients were randomly divided into two groups: the control group submitted to the conventional educational plan, and the experimental group submitted to the educational plan for self-management. Descriptive and analytical statistics were used for the analyzes using the t-test, Fischer’s exact test and Repeated Measures ANOVA. RESULTS Twenty (20) patients were selected. Most participants were male, in advanced stages of disease and undergoing three therapeutic modalities. The control group showed a gradual decrease in quality of life scores during treatment, while the experimental group progressively increased. The correlation was significant between the presence of anxiety and depression symptoms and poor quality of life. Patients in the control group had a significant worsening in social/family well-being (P = 0.02) and the prevalence of additional head and neck cancer-related additional concerns (P = 0.01), while the experimental group had reduced anxiety symptoms (P = 0.001) and improved emotional well-being (P = 0.01). CONCLUSION The educational intervention based on building self-management skills favored quality of life and reduced anxiety and depression. Brazilian Registry of Clinical Trials (RBR 2q53ct).

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Section: Introductionmentioning

confidence: 99%

Quality of life, anxiety and depression in head and neck cancer patients: a randomized clinical trial

Hortense

Bergerot

Domenico

2020

Rev. esc. enferm. USP

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“…All the preventive and curative oral measures should be carried out with the consultation of haematologist or podiatrist oncologist in charge. 12,13 As observed from the previous literature, oral complications at this stage included mucositis, gingival bleeding, oral candidiasis, herpes simplex, xerostomia and bacterial infections. Chemotherapy-associated oral mucositis occurs due to interference with epithelial cell turnover and induction of apoptosis.…”

Section: Discussionmentioning

confidence: 69%

Assessment of Frequency of Oral Conditions in Patients with Hematological Malignancies: A Hospital-Based Study

Gupta¹,

Mahajan²,

Singh³

et al. 2019

IJCMSR

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“…In the recent study about patients who underwent superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer, the professional oral health care reduced the total dose of morphine for the pain control and shortened the hospital days, indicating the utility of professional oral care [ 14 ]. In the recent randomized controlled pilot study in hospitalized patients with acute myeloid leukemia awaiting HSCT, the incidence of OM was 100%, and the highest OM grade was lower in strict oral care self-management support protocol group (OM grade 2) than in usual care group (OM grade 3) [ 15 ]. OM durations were shorter in oral care support protocol group than in usual care group, and OM onset was also later in oral care protocol group than usual care group [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Intensity and duration of neutropenia relates to the development of oral mucositis but not odontogenic infection during chemotherapy for hematological malignancy

et al. 2017

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BackgroundD-index which combines the intensity and duration of neutropenia is reported as a tool for evaluating the dynamics of neutropenia. This study aimed to analyze the relationship between D-index and oral complications (i.e., oral mucositis [OM] and odontogenic infection [OI]) during chemotherapies for hematological malignancies.MethodsA total of 421 chemotherapeutic courses in 104 patients were analyzed. Chemotherapeutic courses in patients who finished all of the prophylactic dental treatments were defined as “treatment Finish”. Chemotherapeutic courses in patients who did not finish prophylactic dental treatments were defined as “treatment not-Finish”. OM was evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. D-index was compared between chemotherapeutic courses with versus without oral complications.ResultsD-index was significantly higher in chemotherapeutic courses with grade 1 or 2 OM (p < 0.001) than courses without OM. In contrast, higher D-index did not relate to the development of OI (p = 0.18). The occurrence of OI (p < 0.001) but not OM (p = 0.56) during chemotherapy was significantly higher in chemotherapeutic courses without the completion of dental intervention.ConclusionsHigher D-index relates to the development of OM. In contrast, OI occurs due to untreated odontogenic foci, and its occurrence does not relate to higher D-index.

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An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study

Abstract: OrCaSS is a promising intervention to delay and reduce OM. These results can serve to plan a larger RCT.

Cited by 25 publications

References 41 publications

Quality of life, anxiety and depression in head and neck cancer patients: a randomized clinical trial

Quality of life, anxiety and depression in head and neck cancer patients: a randomized clinical trial

Assessment of Frequency of Oral Conditions in Patients with Hematological Malignancies: A Hospital-Based Study

Intensity and duration of neutropenia relates to the development of oral mucositis but not odontogenic infection during chemotherapy for hematological malignancy

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