An osteoconductive collagen/hyaluronate matrix for bone regeneration

Liu, LinShu; Thompson, Andrea Y.; Heidaran, Mohammad A.; Poser, James W.; Spiro, Robert C.

doi:10.1016/s0142-9612(99)00006-x

Cited by 168 publications

(84 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The implanted hydrogel matrices were completely integrated into the new reparative bone. More bony healing was observed in HA/COL implants than in glutaraldehyde cross-linked COL, indicating the HA presence enhanced new bone formation [52].…”

Section: Hyaluronate and Hyaluronate/collagenmentioning

confidence: 91%

“…Engineered HA/COL matrices have shown great potential in bone and cartilage repair [47][48][49][50][51][52][53]. The bio-polymer/polymer hybrids were prepared by a ring-opening oxidization reaction resulting in HA with active aldehyde groups attached to the sugar chains, which were then reacted with COL under conditions so that the covalent bonds were formed between the two biopolymers.…”

Section: Hyaluronate and Hyaluronate/collagenmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

et al. 2012

Self Cite

View full text Add to dashboard Cite

Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention. The inclusion of a second biopolymer strengthens the stability of resultant hydrogels and enriches its functionalities by bringing in new functional groups or optimizing the micro-environmental conditions for certain biological and biochemical processes. This article presents approaches that have been used by our groups to synthesize biopolymer hybrid hydrogels for effective uses for immunotherapy, tissue regeneration, food and functional food applications. The research has achieved some challenging results, such as stabilizing physical structure, increasing mucoadhesiveness, and the creation of an artificial extracellular matrix to aid in guiding tissue differentiation.

show abstract

Section: Hyaluronate and Hyaluronate/collagenmentioning

confidence: 91%

Section: Hyaluronate and Hyaluronate/collagenmentioning

confidence: 99%

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been acknowledged that the specific interaction of cells with their surrounding extracellular matrix (ECM) is responsible for promoting and regulating repair processes of the tissue. Regeneration of the lost or damaged tissue requires the reparative cells adhere, migrate, grow and differentiate in the synthesis of a new tissue (Liu et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Collagen/hyaluronan membrane as a scaffold for chondrocytes cultivation

et al. 2009

View full text Add to dashboard Cite

Rabbit chondrocytes were cultivated in vitro using the collagen/hyaluronan membrane. The membrane did not show any adverse effects on chondrocyte viability during in vitro cultivation. The inoculated cells grew without any negative changes. According to the histochemical analyses: (i) hematoxylin and eosin; (ii) safranin O; and (iii) rabbit anti-human collagen type II staining, the rabbit chondrocytes maintained their morphology and phenotype during in vitro cultivation. The collagen/hyaluronan membrane became more stable and stiffer after long time cultivation. The proliferation of the chondrocytes stabilised the structure of the membrane. The collagen/hyaluronan membrane is suitable material for the chondrocyte growth and could provide functional tissue-engineered scaffold for cartilage repair.

show abstract

“…The resulting polymers were biocompatible and could further be used for drug-coupling (HA-mitomycin C) [19,20], fluorescent probe attachment (HA-BODIPY) [15], hydrogel formation via cross-linking [21,22] or photopolymerization [23]. In addition, the hydroxyl groups of HA have been sulfated [24,25,26,27], vicinal diols oxidized to dialdehydes with periodate [28,29], esterified [30], etherified [31,32], and coupled via an isourea intermediate [33]. Functionalities such as amides, hydrazides, and thiols were also chemically introduced as pendant groups for further crosslinking.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and chondroprotective properties of a hyaluronan thioethyl ether derivative

2008

View full text Add to dashboard Cite

Hyaluronan (HA), a non-sulfated glycosaminoglycan, is widely used in the clinic for viscosurgery, viscosupplementation, and treatment of osteoarthritis. Four decades of chemical modification of HA have generated derivatives in which the biophysical and biochemical properties, as well as the rates of enzymatic degradation in vivo have been manipulated and tailored for specific clinical needs. One earlier modification adds multiple thiol groups to HA through hydrazide linkages, leading to a readily crosslinkable material for adhesion prevention and wound healing. We now describe the synthesis and chemical characterization of a novel thioethyl ether derivative of HA, HA-sulfhydryl (HASH), with a minimal tether between the HA and the thiol group. Unlike earlier thiol-modified HA derivatives, HASH cannot be readily crosslinked to form a hydrogel using either oxidative or bivalent electrophilic conditions, thus offering a unique polymeric polythiol that remains soluble. Moreover, HASH showed no cytotoxicity towards primary human fibroblasts and reduced the apoptosis rates of primary chondrocytes exposed to hydrogen peroxide in vitro. These properties foreshadow the clinical potential of HASH to moderate inflammation and to act as a chondroprotective agent in vivo.

show abstract

An osteoconductive collagen/hyaluronate matrix for bone regeneration

Cited by 168 publications

References 0 publications

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

Collagen/hyaluronan membrane as a scaffold for chondrocytes cultivation

Synthesis, characterization and chondroprotective properties of a hyaluronan thioethyl ether derivative

Contact Info

Product

Resources

About