An Outbreak of a New Coronavirus Infection COVID-19 in an Educational Institution in Moscow

Principles of Rational COVID-19 Therapy in Pediatrics

“…In Russia, they focus on five working criteria for the severity of the COVID-19 course (asymptomatic course, mild course, moderate course, severe course, and critical course) [31,53].…”

“…It is noteworthy that scientists from China consider the drug insufficiently studied, and British pediatricians have raised the age threshold for taking remdesivir to 12-17 years [19,56]. In Russia, remdesivir has been recommended since 2021 for the treatment of children older than 12 years and weighing more than 40 kg in hospital treatment [53].…”

“…Umifenovir and recombinant interferon α-2β are recommended for the prevention and treatment of COVID-19 in children by Russian infectious diseases specialists [16,31,[43][44][45][46][47][48][49][50][51][52][53][58][59][60][61][62][63][64]. It is worth noting that the tactics of pharmacotherapy based on the use of interferon contradict the recommendations of the WHO and CDC, which defend a categorical position in the absence of an evidence base for the use of the designated drug [39,55].…”

“…Intravenous immunoglobulins (IVIG) are recommended for use in the development of multisystem inflammatory syndromes in Russia, China, and the USA [16,30,31,39,53,56]. The drugs are usually used in the case of a severe and critical course of the disease in pediatric patients in combination with acetylsalicylic acid and glucocorticosteroids.…”

“…Currently, from the group of recombinant human monoclonal antibodies of the IGG1 class to SARS-CoV-2, sotrovimab is used in pediatric practice in Russia and the UK [19,53]. The Russian recommendations also include combinations of bamlanivimab + etesevimab and kazirivimab + imdevimab.…”