An outbreak of candidemia due to <i>Candida tropicalis</i> in a neonatal intensive care unit

Chowdhary, Anuradha; Becker, Karsten; Fegeler, W.; Gugnani, H. C.; Kapoor, Lata; Randhawa, V S; Mehta, Geeta

doi:10.1046/j.1439-0507.2003.00883.x

Cited by 37 publications

(13 citation statements)

References 29 publications

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“…Various outbreaks caused by NAC species in the NICU setting have been reported previously, mainly caused by C. parapsilosis and C. tropicalis . [678]…”

Section: Discussionmentioning

confidence: 99%

“…Resistance to azole compounds have been reported previously and is rapidly increasing particularly among NAC species. [71011] None of the isolates were found resistant to AMB. With the exception of some C. lusitaniae and Candida haemulonii strains, the occurrence of AMB resistance among Candida spp.…”

Section: Discussionmentioning

confidence: 99%

“…[5678] Many of the other investigators did not find a common source, but outbreak was controlled after optimization of infection control policies.…”

Section: Introductionmentioning

confidence: 99%

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An outbreak of neonatal Candidemia due to non-albicans Candida species in a resource constrained setting of Uttarakhand State, India

et al. 2013

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This case report describes the outbreak of candidemia caused by non-albicans Candida (NAC) species, which within a short period of 11 days, affected six neonates housed in the same room of neonatal intensive care unit of a rural tertiary care center in Uttarakhand state, India. The NAC species isolated showed complete resistance to azole compounds tested. All the neonates were having central venous catheters at the time of diagnosis, received total parenteral nutrition and were on broad spectrum antibiotics. Though two neonates survived the infection, but four of them had an unfortunate outcome and they died despite of aggressive therapy with amphotericin B. It was concluded that candidemia was associated with previously described risk factors and that poor infection control practices were likely responsible for outbreak.

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“…Various outbreaks caused by NAC species in the NICU setting have been reported previously, mainly caused by C. parapsilosis and C. tropicalis . [678]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An outbreak of neonatal Candidemia due to non-albicans Candida species in a resource constrained setting of Uttarakhand State, India

et al. 2013

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“…Outbreaks with species such as Candida parapsilosis and Candida tropicalis do occur, typically among patients in neonatal intensive care units, and have been associated with transmission via health-care workers’ hands or environmental surfaces. 59–61 Outbreaks of Candida auris , a newly emerging, multidrug-resistant yeast, have occurred in the UK and several other countries; early evidence suggests that C auris might be transmitted in health-care settings. 62,63 …”

Section: Health-care-associated Outbreaksmentioning

confidence: 99%

Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks

Benedict

Richardson

Vallabhaneni

et al. 2017

The Lancet Infectious Diseases

112

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Several high-profile outbreaks have drawn attention to invasive fungal infections (IFIs) as an increasingly important public health problem. IFI outbreaks are caused by many different fungal pathogens and are associated with numerous settings and sources. In the community, IFI outbreaks often occur among people without predisposing medical conditions and are frequently precipitated by environmental disruption. Health-care-associated IFI outbreaks have been linked to suboptimal hospital environmental conditions, transmission via health-care workers’ hands, contaminated medical products, and transplantation of infected organs. Outbreak investigations provide important insights into the epidemiology of IFIs, uncover risk factors for infection, and identify opportunities for preventing similar events in the future. Well recognised challenges with IFI outbreak recognition, response, and prevention include the need for improved rapid diagnostic methods, the absence of routine surveillance for most IFIs, adherence to infection control practices, and health-care provider awareness. Additionally, IFI outbreak investigations have revealed several emerging issues, including new populations at risk because of travel or relocation, occupation, or immunosuppression; fungal pathogens appearing in geographical areas in which they have not been previously recognised; and contaminated compounded medications. This report highlights notable IFI outbreaks in the past decade, with an emphasis on these emerging challenges in the USA.

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“…C . tropicalis also has a propensity to be associated with nosocomial outbreaks [10–12]. Furthermore, in some regions, increasing resistance to azoles has been reported in C .…”

Section: Introductionmentioning

confidence: 99%

Novel Polymorphic Multilocus Microsatellite Markers to Distinguish Candida tropicalis Isolates

et al. 2016

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Candida tropicalis is an important pathogen. Here we developed and evaluated a polymorphic multilocus microsatellite scheme employing novel genetic markers for genotyping of C. tropicalis. Using 10 isolates from 10 unique (separate) patients to screen over 4000 tandem repeats from the C. tropicalis genome (strain MYA-3404), six new candidate microsatellite loci (ctm1, ctm3, ctm8, ctm18, ctm24 and ctm26) were selected according to amplification success, observed polymorphisms and stability of flanking regions by preliminary testing. Two known microsatellite loci CT14 and URA3 were also studied. The 6-locus scheme was then tested against a set of 82 different isolates from 32 patients. Microsatellite genotypes of isolates from the same patient (two to five isolates per patient) were identical. The six loci produced eight to 17 allele types and identified 11 to 24 genotypes amongst 32 patients’ isolates, achieving a discriminatory power (DP) of 0.76 to 0.97 (versus 0.78 for both CT14 and URA3 loci, respectively). Testing of a combination of only three loci, ctm1, ctm3 and ctm24, also achieved maximum typing efficiency (DP = 0.99, 29 genotypes). The microsatellite typing scheme had good correlation compared with pulsed-field gel electrophoresis, although was slightly less discriminatory. The new six-locus microsatellite typing scheme is a potentially valuable tool for genotyping and investigating microevolution of C. tropicalis.

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An outbreak of candidemia due to Candida tropicalis in a neonatal intensive care unit

Cited by 37 publications

References 29 publications

An outbreak of neonatal Candidemia due to non-albicans Candida species in a resource constrained setting of Uttarakhand State, India

An outbreak of neonatal Candidemia due to non-albicans Candida species in a resource constrained setting of Uttarakhand State, India

Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks

Novel Polymorphic Multilocus Microsatellite Markers to Distinguish Candida tropicalis Isolates

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