An outbreak of haemorrhagic septicaemia associated with <i>Pasteurella multocida</i> subsp <i>gallicida</i> in a large pig herd

Cameron, R. D. A.; O’Boyle, D.; Frost, A. J.; Gordon, Anita N.; Fegan, Narelle

doi:10.1111/j.1751-0813.1996.tb09949.x

Cited by 22 publications

(16 citation statements)

References 4 publications

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“…There is no known connection between the four Queensland piggeries that yielded these four isolates. Isolates of subsp gallicida are not common in pigs, with the case report of Cameron et al 16 and our previous phenotypic study 4 being the only reports of this subspecies in pigs. There have been few previous studies on the genetic diversity of isolates of subsp gallicida.…”

Section: Resultsmentioning

confidence: 87%

“…4,16,17 Bisgaard et al 18 have noted that some isolates of the subspecies multocida and septica obtained from calf lungs were lactose-positive. Given the rare reporting of lactose-positive isolates in pigs, our finding of nine lactose-positive biovar 12 isolates of very limited genetic diversity in Australian pigs is unusual.…”

Section: Resultsmentioning

confidence: 99%

“…One of the gallicida isolates included in the current study was isolated as the causative agent of a very severe outbreak of septicaemia that killed over 2000 pigs. 16 As this study has suggested that all available Australian isolates of P multocida subsp gallicida are genetically closely related, further studies investigating the pathogenic potential for this subspecies in pigs would appear worthwhile.…”

Section: Resultsmentioning

confidence: 99%

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Ribotype diversity of porcine Pasteurella multocida from Australia

Bowles¹,

Pahoff²,

Smith³

et al. 2000

Aust Veterinary J

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Objective To use the technique of ribotyping to investigate the genetic diversity of Australian isolates of Pasteurella multocida associated with outbreaks of clinical disease in Australian pigs. Design One hundred and seven porcine P multocida isolates were analysed by ribotyping using the restriction enzymes HpaII and HindIII. The genetic population structure of the Australian porcine P multocida isolates was determined through statistical analysis of the joint ribotype patterns, and this was then compared with biochemical and epidemiological data available for the population. Results A total of 25 combined ribotypes were recognised, which were grouped into five ribotype clusters. Despite the deliberate selection of diverse isolates, the study revealed only a limited degree of genetic diversity. Fourteen of the ribotypes contained multiple isolates, and 12 of these ribotypes were present on more than one farm. Three of the seven biovars analysed in the study showed very limited diversity. All fifteen biovar 2 isolates (subsp multocida) were found in a single cluster (III), while all four biovar 8 isolates, which correspond to P multocida subsp gallicida, were allocated by themselves to a single cluster (IV). All nine of the biovar 12 isolates (lactose‐positive subsp multocida) were assigned to a single cluster (I), together with the single biovar 14 isolate, which was the only other lactose‐positive isolate in the population (ODC‐negative). Conclusion A limited number of ribotypes of P multocida are associated with Australian pigs. The majority of these ribotypes are widely distributed across multiple farms, and across multiple states. Individual farms can possess multiple ribotypes of P multocida. Some of the unusual biochemical variants of P multocida present in Australian pigs have a very limited genetic diversity. The nature of pig production in Australia, primarily involving continuous flow systems with few closed herds, has possibly contributed to the widespread distribution of a limited number ribotypes.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Ribotype diversity of porcine Pasteurella multocida from Australia

Bowles¹,

Pahoff²,

Smith³

et al. 2000

Aust Veterinary J

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“…Septicaemia in pigs caused by P. multocida type A has been described in a few experimental studies (Smith et al 1973, Ono et al 2003 and in cases of natural infections (Pijoan & Fuentes 1987, Mackie et al 1992, Cameron et al 1996, Blackall et al 2000Thomson et al 2001, Pors et al 2011a). According to these publications, both experimental and natural infections have resulted exclusively in respiratory disease, and this may suggest the existence of strains expressing different determinants of pathogenicity, and some expressing factors determining the invasiveness of the bacteria.…”

Section: Discussionmentioning

confidence: 99%

Pasteurella multocida type A as the primary agent of pneumonia and septicaemia in pigs

et al. 2015

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In order to understand better the pathological aspects and spread of Pasteurella multocida type A as the primary cause of pneumonia in pigs, was made an experiment with intranasal inoculation of different concentrations of inocula [Group (G1): 108 Colony Forming Units (CFU)/ml; G2: 107 CFU/ml; G3: 106 CFU/ml and G4: 105 CFU/ml], using two pigs per group. The pigs were obtained from a high health status herd. Pigs were monitored clinically for 4 days and subsequently necropsied. All pigs had clinical signs and lesions associated with respiratory disease. Dyspnoea and hyperthermia were the main clinical signs observed. Suppurative cranioventral bronchopneumonia, in some cases associated with necrosuppurative pleuropneumonia, fibrinous pericarditis and pleuritic, were the most frequent types of lesion found. The disease evolved with septicaemia, characterized by septic infarctions in the liver and spleen, with the detection of P. multocida type A. In this study, P. multocida type A strain #11246 was the primary agent of fibrinous pleuritis and suppurative cranioventral bronchopneumonia, pericarditis and septicaemia in the pigs. All concentrations of inoculum used (105-108 CFU/ml) were able to produce clinical and pathological changes of pneumonia, pleuritis, pericarditis and septicemia in challenged animals.

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“…Septicemic disease caused by P. multocida is well recognized in cattle and buffalo. 7 In domestic pigs, sporadic outbreaks have been reported in several countries of the eastern hemisphere, 2,8,9 being extremely uncommon in Europe where only 1 outbreak has been reported in Germany. 13 Pasteurella multocida has been previously isolated from wild boar and linked with a case of PAR, 6 but has not been associated with any outbreak of acute septicemia.…”

Section: Research-article2013mentioning

confidence: 99%

Fatal outbreak of systemic pasteurellosis in a wild boar (Sus scrofa) population from southwest Spain

et al. 2013

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Pasteurella multocida is a common pathogen of swine that causes specific diseases with great economic impact. However, the importance of this pathogen in wild boar is still unknown. In the current work, an outbreak of systemic pasteurellosis in wild boar with a high mortality rate is described. A total of 23 wild boar of all ages were found dead over a 5-day period on a game estate in southwest Spain (11.11% mortality). Three animals were necropsied and showed subcutaneous edema, a generalized congestion, and fibrin deposits in the peritoneal cavity. Hemorrhages, general congestion, and intravascular thrombosis were microscopically observed. Pasteurella multocida type B was isolated from all of the studied organs. Outbreaks of systemic pasteurellosis have been described in domestic pigs from Asia and Australia, but not to date in Europe. This outbreak suggests that systemic pasteurellosis affecting wild boar populations may be an important cause of mortality.

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An outbreak of haemorrhagic septicaemia associated with Pasteurella multocida subsp gallicida in a large pig herd

Cited by 22 publications

References 4 publications

Ribotype diversity of porcine Pasteurella multocida from Australia

Ribotype diversity of porcine Pasteurella multocida from Australia

Pasteurella multocida type A as the primary agent of pneumonia and septicaemia in pigs

Fatal outbreak of systemic pasteurellosis in a wild boar (Sus scrofa) population from southwest Spain

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