“…2,20,21 Epidemiologic data indicate that structural coronary arterial abnormalities and their consequences cause 80% of the cases of VF or pulseless VT, 2,20,22 dilated and hypertrophic cardiomyopathies account for the second largest proportion of 10-15% 2,20 and other cardiac disorders, such as primary electrical and genetic ion-channel abnormalities, valvular or congenital heart disease, account for only a small proportion. 2,20 Although small-scale studies of sudden cardiac death, such as those involved in the WHO-MONICA project 23,24 or autopsy, 25 have reported that the incidence of sudden cardiac death from acute coronary syndrome is lower among patients with out-of-hospital cardiac arrest in Japan than in Europe and the USA, 3 large-scale Japanese studies that used the Utstein guidelines have demonstrated that cardiac etiology accounted for the largest proportion (>50%) of patients with out-of-hospital cardiac arrest, [13][14][15][16] and the proportion of cases of VF or pulseless VT as the first cardiac rhythm was approximately 10% of thoses who were in cardiac arrest before the arrival of EMS personnel who gave CPR. [13][14][15][16] On the other hand, Nagao et al also used the Utstein guidelines and showed that the proportion of VF or pulseless VT as the first cardiac rhythm was 38% with a mean call-to-scene interval of approximately 5.5 min, 26 and the cause of VF was acute coronary syndrome in 78%, which included the initial angiogram of the acute coronary syndrome related artery that had Thrombolysis in Myocardial Infarction flow grade 0-2 in 77%.…”