An outlook on microfluidics: the promise and the challenge

Battat, Sarah; Weitz, David A.; Whitesides, George M.

doi:10.1039/d1lc00731a

Cited by 192 publications

(105 citation statements)

References 82 publications

(128 reference statements)

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“…These methods produce structures with good resolution and surface roughness, however, they require skilled labor, and special equipment and facilities which make the transition to the commercial market difficult. [ 239 ] As a result, researcher explore for alternative materials that are cheap, easy to process, and can transition to large scale production economically. In addition, novel materials should exhibit high chemical‐solvent compatibility, surface modification and functionalization, and ability to incorporate inlet/outlet ports.…”

Section: Discussionmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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Cyclic olefin copolymers (COC) are amorphous, transparent thermoplastics composed of cyclic olefin monomers (norbornene) and linear olefins (ethene). They are increasingly utilized as fabrication materials for microsystems and microfluidic devices, owing to their promising features of low water absorption, high electrical insulation, long-term stability of surface treatments, and resistance to a broad variety of acids and solvents. Many manufacturing processes for COC-based devices have been developed in recent decades. These methodologies are categorized as replication methods or fast prototyping as common in fabrication of thermoplastic microfluidic devices. This review gives a full discussion of the features of COCs, the various production processes, and the numerous selected applications in microfluidic platforms. The review also explores COC's composition and fundamental features, as well as fabrication processes and applications in a variety of fields, investigates the material's potential advantages and uses, and attempts to create a comprehensive list of COC's possible benefits. Due to their unique features and simplicity of fabrication, COCs are projected to advance the future of microfluidics, microsystems, and optofluidics.

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Section: Discussionmentioning

confidence: 99%

A Review of Cyclic Olefin Copolymer Applications in Microfluidics and Microdevices

Agha

Waheed

Alamoodi

et al. 2022

Macro Materials & Eng

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“…Although the above-mentioned conventional electrofusion systems can complete a large number of cell electrofusion at one time, they have limited capabilities in cell control at a single-cell level [15,16] , leading to precise electrofusion of specific cells. In recent years, the electrofusion systems are gradually developing single-cell methods and improving precision.…”

Section: Microfluidic Electrofusion Chipmentioning

confidence: 99%

Advances in hybridoma preparation using electrofusion technology

Kou

Shen

wang

et al. 2022

Preprint

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As a rapidly developing cell engineering technique, cell electrofusion has been increasingly applied in the field of hybridoma preparation in recent years. However, electrofusion is a certain degree of difficulty to completely replace the polyethylene glycol-mediated cell fusion. The key elements limiting electrofusion in the field of hybridoma preparation are practical complicated. This review summarizes the state of art of cell electrofusion in hybridoma preparation based on recent published literatures, mainly focusing on electrofusion instruments and their components, process control, cell treatment, and process characterization. The review provides new information and insightful commentary, critically important to the promotion of further electrofusion development in the field of hybridoma preparation.

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“… 4 As recently stated by Battat, Weitz, and Whitesides, wide adoption of microfluidic platforms has been limited by the complexity in the design, fabrication, and operation of custom devices that limit its reproducibility and generalizability. 5 While fabrication can be outsourced (albeit at significant cost), microfluidic design and operation can require months to years of multiple “design-build-test” iterations to optimize performance.…”

Section: Introductionmentioning

confidence: 99%