Background: In 2007, the Japanese Orthopaedic Association (JOA) proposed the term "Locomotive syndrome" (LS) to describe a condition in high-risk patients with musculoskeletal disease. So far, there are many studies that are designed for non-handicapped people. However, the study using a cohort of handicapped people are limited. In this study, we therefore conducted a study on LS in lower amputees. Methods and Participants: We surveyed 47 lower amputees. A questionnaire that included the 25question Geriatric Locomotive Function Scale (GLFS-25) and the Loco-check was distributed to the participants.