An outstanding cyclocondensation of 2-aminopyrazine

Valdo, Ana Karoline Silva Mendanha; Guimarães, Fernando; Martins, Felipe Terra

doi:10.1016/j.molstruc.2021.130723

Cited by 1 publication

(1 citation statement)

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“…Novel and eco-efficient methods are desperately needed in chemistry, which is an ever-evolving field to synthesis complex organic compounds [1]. Heteroaromatic molecule of 2-aminopyrazine is composed of two azanitrogen atoms with a single electron pair that promotes nucleophilic reactions and one primary amine promotes electrophilic reactions [2]. 4H-Chromene is an important heterocyclic compound, and its unique structure and biological properties have made it a valuable target for medicinal chemists in the development of new drug candidates [3,4].…”

Section: Introductionmentioning

confidence: 99%

2‐Aminopyrazine catalyzed three‐component and one‐pot construction of 2‐amino‐4H‐chromene‐3‐carbonitrile by mortar‐pestle grinding and molecular docking studies

Edapu,

Boodida,

Pagadala

et al. 2024

J Chinese Chemical Soc

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A highly efficient and environmentally friendly method for the synthesis of 2‐amino‐4H‐chromene‐3‐carbonitrile (ACC) derivatives has been successfully established. This innovative, solvent‐free approach involves a tandem three‐component and one‐pot reaction utilizing arylaldehyde, dicyanomethane, and dimedone/cyclohexane‐1,3‐dione, catalyzed by 2‐aminopyrazine under the mortar‐pestle grinding technique. Key attributes of this synthetic strategy include its simplicity, high efficiency, cost‐effectiveness, absence of column chromatography, shorter reaction times (18–40 min), and consistently high yields (89%–96%). Furthermore, computational studies have been conducted against the 4RHT protein using the synthesized compounds.

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