An Overview and Critical Analysis of Breast Cancer Screening

Lung, John; Hart, Nan E.; Woodbury, Robert A.

doi:10.1001/archsurg.1988.01400310047008

Cited by 8 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This development has led to as much as a 46% reduction in mortality, presumably due to the detection of smaller malignancies at an earlier stage of development that have a lower risk of metastases and death than those larger and more advanced malignancies found by physical examination [1][2][3][4][5][6]. This development has led to as much as a 46% reduction in mortality, presumably due to the detection of smaller malignancies at an earlier stage of development that have a lower risk of metastases and death than those larger and more advanced malignancies found by physical examination [1][2][3][4][5][6].…”

mentioning

confidence: 99%

“…Among the most significant advances attained during the twentieth century in the management of breast carcinoma has been its early detection by mammographic screening. This development has led to as much as a 46% reduction in mortality, presumably due to the detection of smaller malignancies at an earlier stage of development that have a lower risk of metastases and death than those larger and more advanced malignancies found by physical examination [1][2][3][4][5][6].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Management of in situ and minimally invasive breast carcinoma

Frykberg

Bland

1994

World j. surg.

View full text Add to dashboard Cite

In situ breast carcinoma represents an early localized stage in the transition to invasive breast carcinoma and has an especially favorable prognosis with appropriate management. The widespread use of mammography has contributed to its increased rate of diagnosis. The two histologic forms of this entity have distinct pathologic and biologic characteristics, with different therapeutic implications. Lobular carcinoma in situ is considered a marker of increased risk for subsequent invasive carcinoma and is most commonly managed by nonoperative surveillance. Ductal carcinoma in situ behaves more as a true anatomic precursor of invasive disease and has the same therapeutic options as invasive breast carcinoma. Minimally invasive breast carcinoma should be considered a fundamentally different entity, primarily because of its potential for systemic metastasis that in situ lesions do not theoretically have. There are still many outstanding issues and dilemmas to be resolved by scientific investigation before the intriguing potential of these early forms of breast malignancy are fully understood.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Management of in situ and minimally invasive breast carcinoma

Frykberg

Bland

1994

World j. surg.

View full text Add to dashboard Cite

show abstract

“…The significant factor being that at 15 years survival was 77.7% in the screened group versus 68% in the control group. 24 That report contrasts sharply with report of Lung et al 25 from the Mountain States Tumor Institute with only about 25% of their patients with a palpable mass having positive nodes, and with only 1 1 % of those with a positive mammogram only, having positive nodes. Again there was no difference in the two groups to time of relapse.…”

mentioning

confidence: 70%

The importance of clinical breast examination

McGinnis

1989

Cancer

View full text Add to dashboard Cite

New diagnostic, staging, and therapeutic aspects of early breast cancer

Cady

1990

Cancer

View full text Add to dashboard Cite

Many advances have occurred in breast cancer through research and clinical trials. More confidence in new biological consumptions about invasive breast cancer indicate that: (1) details of the primary breast cancer do not control survival; (2) breast-only failures after local excision do not bias against survival; and (3) cancer cell dissemination occurs at the same time via both lymphatic and hematogenous routes. Early detection with mammographic screening has indicated a greater number of smaller breast cancers, including sharp increases in ductal carcinoma in situ (DCIS). With proper analysis and control, DCIS of limited extent can be treated by local excision with or without radiation. Invasive breast cancer of limited extent can frequently be managed by lumpectomy and radiation therapy with survival rates equivalent to the more traditional mastectomy. Patient desires regarding breast preservation and quality of life are paramount. Risk: benefit analyses for individual patients need to be emphasized in issues of breast preservation and in selecting adjuvant therapy, both regional (radiotherapy) and systemic (chemotherapy) and hormonal therapy). We are entering an era of highly selective therapy based on more sophisticated analysis of the primary cancer. In the future, not only statistical predictions of outcome as achieved by flow cytometry, for example, will be more widely used, but individual prognostic factors may be developed such as with oncogene expression. Such individual prognostic factors will enable more selective therapy.

show abstract

An Overview and Critical Analysis of Breast Cancer Screening

Cited by 8 publications

References 11 publications

Management of in situ and minimally invasive breast carcinoma

Management of in situ and minimally invasive breast carcinoma

The importance of clinical breast examination

New diagnostic, staging, and therapeutic aspects of early breast cancer

Contact Info

Product

Resources

About