An Overview and Update on Asthma and its Management

Rajanandh, Muhasaparur Ganesan

doi:10.3923/jms.2015.122.129

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…Asthma is a common lung disease in childhood, which is associated with phlegm and wheezing. The prevalence of asthma is currently increasing worldwide at a rate of 50% every decade, and the number of asthma patients will reach 400 million by 2025 [ 1 ]. According to the statistics of the World Health Organization, there are more than seven million asthmatic children under the age of 18 years in the United States, and the economic burden due to asthma exceeds that of tuberculosis and AIDS combined [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Pingchuan Formula on Toll-Like Receptors and Dendritic Cells in an Asthmatic Mouse Model

Liu

Bai

Xue

et al. 2020

BioMed Research International

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Pingchuan formula (PCF) was created by Professor Yu Jianer. The purpose of this study was to investigate the effect of PCF on dendritic cells (DCs) and toll-like receptors (TLRs) in initiating immunity. A bronchial asthma BALB/c mouse model was established using an OVA excitation method. PCF was immediately administered by gavage after the first excitation. After 7 d, hematoxylin and eosin (HE) staining was used to observe the pathological changes in the asthma model. Eosinophil infiltration and concentrations of IL-4, IFN-r, IL-12, and IFN-α in BALF were determined by enzyme-linked immunosorbent assay (ELISA). Real-time PCR was used to determine mRNA levels of IL-12 and IFN-α. Protein expression levels of ERK, Toll-2, IDO, and Toll-9 were measured by immunoblot. HE and ELISA showed that PCF could improve lung pathological changes and significantly decrease the concentration of IL-4 in BALF. Moreover, PCF could increase IL-12, IFN-α, and IFN-r in BALF. Real-time PCR and western blot showed that PCF restored the DCs and TLRs in initiating immunity. In summary, this study found that PCF can improve the pathological changes and reduce the symptoms of asthma in a BALB/c mouse model. It can facilitate the initiation of immunity by restoring the DCs and TLRs.

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Section: Introductionmentioning

confidence: 99%