An Overview of 2‐Styrylchromones: Natural Occurrence, Synthesis, Reactivity and Biological Properties

Abstract

2-Styrylchromones are a small class of oxygen-containing heterocycles. Despite their sparse occurrence in nature, several synthetic approaches have been developed in order to synthesize a large variety of derivatives, possessing different substituents in different positions of the main core. They are also versatile building blocks in the synthesis of new hetero-

[Retracted] Styrylchromones: Biological Activities and Structure‐Activity Relationship

“…The position of this bond and the ring substituents determine the nomenclature of these compounds. The most common are 2-styrylchromones (2-SC) or 2-styryl-4 H -chromen-4-one ( 1 , Figure 2 ), where the bond occurs at C-2, and some 3-styrylchromones (3-SC) ( 2 , Figure 2 ) are also known [ 3 , 5 ].…”

“…Among the compounds derived from chromones, there is a group characterized by having a styryl group attached to the chromone core, known as styrylchromones (SC) [ 3 ]. Over the years, several biological activities have been attributed to SC, such as antioxidant, anti-inflammatory, antimicrobial, antiviral, antitumor, neuroprotective, and antiallergic [ 3 , 4 ]. This versatility has attracted the attention of several authors to the study of this group of chromones.…”

First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones

“…1,2 This ring system is also a useful substrate for further functionalization, which can be achieved through oxidation, condensation, conjugate addition or Diels-Alder (DA) reactions. 3,4 In fact, a DA reaction is one of the most powerful cycloaddition reactions in organic synthesis and particularly, in the construction of 6-membered rings, combining dienes and dienophiles with different substitution patterns. 5,6 There are countless examples of natural products and other complex structures synthesized through this approach, with an outstanding degree of control and a high level of predictability for this process.…”

Reaction of 2‐Imino‐2H‐chromene‐3‐carboxamide with Phosphorus Isothiocyanates: First Synthesis of Novel Chromeno[2,3‐d]pyrimidinyl and Bis(chromeno[2,3‐d]pyrimidinyl)phosphines and Chromeno[2′,3′:4,5]pyrimido[2,1‐d][1,3,5,2]triazaphosphinine

“…Oxygen‐containing heterocyclic compounds are biologically attractive scaffolds and known as naturally and synthetic bioactive molecules . Among them, some fused polycyclic chromene compounds have received synthetic attention because of their important biological properties such as antioxidant , anticancer , and antimicrobial properties.…”