An Overview of a Novel, Water-Soluble Undenatured Type II Collagen (NEXT-II)

Yoshinari, Orie; Moriyama, Hiroyoshi; Shiojima, Yoshiaki

doi:10.1080/07315724.2014.919541

Cited by 15 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was reported that UC-II supplementation does not affect the NF-κB levels in human synovial MH7A cells. However, in another study, it was shown that UC-II supplementation regulates the NF-κB pathway-related markers (26,38).…”

Section: Discussionmentioning

confidence: 95%

“…However, we showed that UC-II inhibits NF-κB, TNF-α, IL-1β, IL-6, COX-2, and IKK-γ in MIA induced OA rats. Similarly, UC-II supplementation reduced the serum IL-1β, IL-6, and IL-8 and TNF-α levels in collageninduced arthritis (26,38). In addition, in the case of osteoarthritis defined by a subclinical immune disorder and the vicious cycle of inflammatory events, UC-II promoted a reduction in inflammation (10).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Undenatured Type II Collagen Ameliorates Inflammatory Responses and Articular Cartilage Damage in the Rat Model of Osteoarthritis

et al. 2021

View full text Add to dashboard Cite

Osteoarthritis (OA) is an age-related joint disease that includes gradual disruption of the articular cartilage and the resulting pain. The present study was designed to test the effects of undenatured type II collagen (UC-II®) on joint inflammation in the monoiodoacetate (MIA) OA model. We also investigated possible mechanisms underlying these effects. Female Wistar rats were divided into three groups: (i) Control; (ii) MIA-induced rats treated with vehicle; (iii) MIA-induced rats treated with UC-II (4 mg/kg BW). OA was induced in rats by intra-articular injection of MIA (1 mg) after seven days of UC-II treatment. UC-II reduced MIA-induced Kellgren-Lawrence scoring (53.3%, P < 0.05). The serum levels of inflammatory cytokines [IL-1β (7.8%), IL-6 (18.0%), TNF-α (25.9%), COMP (16.4%), CRP (32.4%)] were reduced in UC-II supplemented group (P < 0.0001). In the articular cartilage, UC-II inhibited the production of PGE2 (19.6%) and the expression of IL-1β, IL-6, TNF-a, COX-2, MCP-1, NF-κB, MMP-3, RANKL (P < 0.001). The COL-1 and OPG levels were increased, and MDA decreased in UC-II supplemented rats (P < 0.001). UC-II could be useful to alleviate joint inflammation and pain in OA joints by reducing the expression of inflammatory mediators.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Undenatured Type II Collagen Ameliorates Inflammatory Responses and Articular Cartilage Damage in the Rat Model of Osteoarthritis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This means that active UC-II supplementation alone (10 mg/day for 150 days) was well tolerated and increased the well-being significantly in moderately arthritic dogs [74]. Another water-soluble UC-II form also exhibited similar noteworthy efficiency in relieving pain and inflammation in collagen-induced arthritis in mice, as well as moderately arthritic dogs after 150 days of supplementation with 10 mg of dosage when compared to control dogs [98,99]. In a clinical, randomized, controlled, and prospective study [79], 60 client-owned dogs were randomly allocated to the R group (n = 30, robenacoxib 1 mg/kg/day) and the UC-II group (UC-II 1 tablet (40 mg)/day) for a 30 days study.…”

Section: Uc-ii Usage In Dogsmentioning

confidence: 87%

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals

Gençoğlu

Orhan

Şahin

et al. 2020

Animals

View full text Add to dashboard Cite

OA is quite common in companion animals, especially in large breed dogs and horses. Collagen, the most abundant protein of mammals, has specific connective tissue types for skin, bones, reticulate, basal lamina, bones, cell surfaces, while type II collagen (UC-II) forms the main structure of cartilage tissue. Even at the smaller dosages, UC-II has also been reported to be more effective than the glucosamine and chondroitin sulfate supplements, which are the supplements most frequently used in the market. In this review, we summarize the effects of UC-II on joint health and function in health and disease conditions in companion animals.

show abstract

“…Type II collagen is available in the form of denatured and undenatured types in the market, while previous studies involved undenatured type II collagen, modulating joint health in OA and RA (5,7,15). NEXT-2 has been also examined about safety and efficacy on animal (11)(12)(13). We expected that NEXT-II could be higher in human utilization in respect to its high water-solubility in nature.…”

Section: Discussionmentioning

confidence: 99%

“…We have developed water soluble undenatured type II collagen (NEXT-II ® ) in light of potential delivery in the liquid form. Recently, we reported safety and efficacy in NEXT-II ® on mice, rats and, dogs (11)(12)(13). In the clinical pilot study, the aim is to evaluate the efficacy and safety of NEXT-II ® in subjects who have health concerns of their knee joints.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Efficacy and Safety of NEXT-II®, a Novel Water-Soluble, Undenatured Type II Collagen in Subjects with Potential Risks in the Knee Joint Health from Healthy Population

Yoshinari¹,

Moriyama²,

Shiojima³

et al. 2015

FFHD

Self Cite

View full text Add to dashboard Cite

Background: Oral administration of a novel water-soluble undenatured type II collagen (NEXT-II®) has been demonstrated to ameliorate the signs and symptoms of rheumatoid arthritis (RA) in animal models. In the present investigation, we conducted a pilot study to examine the efficacy and safety of NEXT-II® in borderline subjects defined as healthy and non-diseased state, but with potential risks in knee joint health. Method: We employed Western Ontario McMaster Index (WOMAC) score and Visual Analog Scale (VAS) scores to assess the extent of improvement in the knee joints in these volunteers following supplementation of 40 mg NEXT-II® (10 mg as undenatured type II collagen) over a period of 12 weeks. Result: The results demonstrated that NEXT-II® treatment significantly reduced WOMAC and VAS scores compared to subjects at baseline. Specifically, in the evaluation using VAS, the borderline subjects at resting, walking, and going up and down the stairs revealed significant improvement when compared to the baseline. Conclusion: The results of the studies demonstrated that NEXT-II® might be an ingredient which is safe and effective in the application of dietary supplement in ameliorating joint pain and symptoms of the borderline subjects without any adverse events.

show abstract

An Overview of a Novel, Water-Soluble Undenatured Type II Collagen (NEXT-II)

Cited by 15 publications

References 15 publications

Undenatured Type II Collagen Ameliorates Inflammatory Responses and Articular Cartilage Damage in the Rat Model of Osteoarthritis

Undenatured Type II Collagen Ameliorates Inflammatory Responses and Articular Cartilage Damage in the Rat Model of Osteoarthritis

Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals

Evaluation of Efficacy and Safety of NEXT-II®, a Novel Water-Soluble, Undenatured Type II Collagen in Subjects with Potential Risks in the Knee Joint Health from Healthy Population

Contact Info

Product

Resources

About