An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson’s Disease

Leuk, Jessie Siew-Pin; Low, Linette Li Neng; Teo, Wei‐Peng

doi:10.3389/fnagi.2020.00243

Cited by 14 publications

(10 citation statements)

References 64 publications

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“…Dopaminergic drugs are used to lessen motor symptoms, while adjuvant therapies, such as acoustic-based non-pharmacological interventions, are utilized as a supplement to 10.3389/fnhum.2023.1100431 conventional drug treatments. Numerous studies have shown that rhythmic auditory stimulation (RAS) can help Parkinson's disease sufferers walk more naturally (Lee et al, 2012;Benoit et al, 2014;Leuk et al, 2020). For instance, walking to an audio metronome can reduce timing variability, increase walking speed, and lengthen strides (Benoit et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Aberrant inter-network functional connectivity in drug-naive Parkinson’s disease patients with tremor dominant and postural instability and gait difficulty

Wang

Yan

et al. 2023

Front. Hum. Neurosci.

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Background: Insight into neural mechanisms of tremor dominant (TD) and postural instability and gait disorder (PIGD) subtypes in Parkinson’s disease (PD) is vital for understanding pathophysiological hypotheses underlying this phenotype. However, network disturbances and their correlation with motor subtypes of PD remain unclear. We aimed to investigate the alterations of intra- and inter-network functional connectivity (FC) in drug-naive PD patients with different motor subtypes.Methods: Resting-state functional magnetic resonance imaging was performed on 25 drug-naive PD patients with TD (PD-TD) and 40 drug-naive PD patients with PIGD (PD-PIGD), and 37 healthy controls (HCs) underwent. The following networks were extracted using independent component analysis: sensorimotor network (SMN), left executive control network (LECN), right executive control network, anterior salience network (aSN), posterior salience network (pSN), ventral attention network (VAN), dorsal attention network (DAN), default mode network (DMN), visual network, and auditory network (AN). We measured FC values within and between these networks.Results: There were no detectable variations in intra-network FC. PD-PIGD group demonstrated lower FC between aSN and pSN, as well as between VAN and DMN, in contrast to PD-TD group. Particularly, the FC strength between VAN and DMN was positively correlated with TD and tremor scores, and the best fitting classification models of TD and PIGD subtypes were based on the FC between aSN and pSN. Compared with HCs, both PD-TD and PD-PIGD patients displayed decreased FC between two SMN subnetworks, while PD-TD patients exhibited increased FC between the SMN subnetwork and pSN, and between LECN and VAN. Furthermore, PD-PIGD patients demonstrated decreased FC between the SMN subnetwork and AN.Conclusions: The altered FC between aSN and pSN can be an imaging marker to distinguish PD-TD from PD-PIGD. We for the first time disclosed that the PD-TD patients compensated by increasing attention resources and the PD-PIGD patients displayed reduced FC between SMN and AN. Our findings provide a basis for identification and precision treatment of PD motor subtypes.

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Section: Discussionmentioning

confidence: 99%

Aberrant inter-network functional connectivity in drug-naive Parkinson’s disease patients with tremor dominant and postural instability and gait difficulty

Wang

Yan

et al. 2023

Front. Hum. Neurosci.

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“…Two main hypotheses have been formulated to explain how RAS may compensate the timing deficit in PD, the compensation and restoration hypotheses (for review, see [ 50 ]). The compensation theory proposes that areas other than the basal ganglia are activated to substitute the basal ganglia in rhythm perception and are linked to the internal processing of timing.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Exercise Intervention with Rhythmic Auditory Stimulation to Improve Gait and Mobility in Parkinson Disease: An Umbrella Review

2021

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Difficulties in walking, controlling balance, and performing activities of daily living are common problems encountered by individuals affected by Parkinson disease. Scientific evidence suggests that exercise performed with music or auditory or rhythmical cues facilitates movement and improves balance, gait, mobility, and activities of daily living (ADL) performance in patients with PD. The aim of this umbrella review was to summarize available high-quality evidence from systematic reviews and meta-analyses on the effectiveness of rhythmically cued exercise to improve gait, mobility, and ADL performance in individuals with PD. PubMed, Cochrane, and Embase databases were searched from January 2010 to October 2020 for systematic reviews and meta-analyses which had to be (1) written in English, (2) include studies on populations of males and females with PD of any age, (3) analyze outcomes related to gait, mobility, and ADL, and (4) apply exercise interventions with music or auditory or rhythmical cues. Two independent authors screened potentially eligible studies and assessed the methodological quality of the studies using the AMSTAR 2 tool. Four studies, two systematic reviews and meta-analyses, one a systematic review, and one a meta-analysis, were selected. Overall results indicated positive effects for gait and mobility of the use of rhythmic auditory cueing with exercise and suggested that it should be incorporated into a regular rehabilitation program for patients affected by PD. Nonetheless, more primary level research is needed to address the identified gaps regarding the application of this method to physical exercise interventions.

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“…A digital therapeutic platform (MedRhythms Inc.) has been designed to improve walking outcomes by digitizing a well-established, evidence-based intervention known as Rhythmic Auditory Stimulation (RAS). RAS is an approached used in rehabilitation in which external auditory cues (e.g., beat of a metronome) are applied to facilitate entrainment or the ability to synchronize movements (i.e., walking) to a beat [ 9 ]. Several studies reveal the beneficial effects of RAS in improving spatiotemporal parameters of gait in PD [ 10 ], but translation of this approach into digital therapeutics is just beginning.…”

Section: Digital Therapeutics To Improve Walking Outcomesmentioning

confidence: 99%

Digital Therapeutics in Parkinson’s Disease: Practical Applications and Future Potential

Ellis

Earhart

2021

JPD

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Digital therapeutics, treatments delivered remotely and enabled by modern technology, facilitate the provision of personalized, evidence-based, interdisciplinary interventions to manage the complexities associated with Parkinson’s disease. In the context of the COVID-19 pandemic, the need for digital therapeutics has arguably never been greater. However, despite new advances in technology and a heightened interest due to the pandemic, digital therapeutics remain underdeveloped and underutilized. In this paper, we briefly review practical applications and emerging advances in digital therapeutic platforms that target motor and non-motor signs and healthy lifestyle behaviors such as regular exercise, a healthy diet and optimal sleep hygiene habits. Future applications which could transform personalized self-management and patient care are presented. Opportunities, drawbacks and barriers to access are discussed.

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An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson’s Disease

Cited by 14 publications

References 64 publications

Aberrant inter-network functional connectivity in drug-naive Parkinson’s disease patients with tremor dominant and postural instability and gait difficulty

Aberrant inter-network functional connectivity in drug-naive Parkinson’s disease patients with tremor dominant and postural instability and gait difficulty

The Impact of Exercise Intervention with Rhythmic Auditory Stimulation to Improve Gait and Mobility in Parkinson Disease: An Umbrella Review

Digital Therapeutics in Parkinson’s Disease: Practical Applications and Future Potential

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