An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids

doi:10.4172/jbb.1000171

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“…The literature reveals various analytical methods were described for the determination of LNP such as titrimetric [5,6], Spectrophotometric [7][8][9][10][11][12][13][14][15], spectrofluorometric [16][17][18][19][20], chromatographic [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], derivative UV-spectrophotometric, [39][40] polarography [41][42], radioimmunoassay [43] and fluoroimmunoassay [44].…”

Section: Introductionmentioning

confidence: 99%

Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

zounr

2021

Pak J Anal Environ Chem

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An easy, sensitive and accurate spectrophotometric method has been developed for the determination of Lisinopril (LNP) in pure and tablet formulations based on derivatization reaction with 2-hydroxynaphthaldehyde (2HNA). The derivatization reaction was carried out in methanol solvent at pH-5.5 at 95±2C for 15 min. The linear calibration curve was obtained that obeyed the Beer’s law within the concentration range 5-50 μgmL-1 of LNP at 433 nm with a coefficient of determination R²=0.996. The recovery was in the range from 98.25-101.82 with molar absorptivity of drug 9×103 mole-1cm-1. The method was accurate and precise (intra-day variation 0.05-0.97% and inter-day 0.07-1.6%), with limit of detection (LOD) and limit of quantification (LOQ) 0.264 μgmL-1 and 0.8 μgmL-1, respectively. No interferences from the excipients were detected. The method was applied for the rapid analysis of LNP in pharmaceutical products.

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Section: Introductionmentioning

confidence: 99%

Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

zounr

2021

Pak J Anal Environ Chem

View full text Add to dashboard Cite

show abstract

An Overview of Analytical Determination of Captopril in Active Pharmaceutical Ingredients (API) Formulation and Biological Fluids

Cited by 1 publication

References 34 publications

Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

Determination of Lisinopril in Pure and Tablet form by Using 2-Hydroxynaphthaldehyde as Derivatizing Reagent

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