An overview of anti-epileptic therapy management of patients with malignant tumors of the brain undergoing radiation therapy

Julie, Diana; Ahmed, Zartaj; Karceski, Stephen C.; Pannullo, Susan C.; Schwartz, Theodore H.; Parashar, Bhupesh; Wernicke, A. Gabriella

doi:10.1016/j.seizure.2019.06.019

Cited by 12 publications

(13 citation statements)

References 99 publications

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“…Surgical treatment, radiotherapy, or chemotherapy reduce tumor load and improve cognitive functioning but can also cause cognitive deficits [ 6 , 48 ]. For example, surgery most affects memory and executive function [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

“…Data on the incidence of metastases to the brain also vary, but the US National Brain Tumor Society report at least twice as many secondary brain cancer diagnoses than primary brain cancer diagnoses each year, although there are reports of 10-times more secondary than primary diagnoses. Regardless, brain metastases are common, affecting 10–30% of patients with cancer and most commonly arising from primary lung (30–40%), breast (5–19%), skin (melanoma; 7–10%), and colon and rectum (7%) cancers [ 1 , 3 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Epilepsy is rarer in patients with metastatic lesions (15–25%), with melanoma metastases conferring the greatest risk of seizure (11–33% [ 6 ]) followed by lung metastases (12.5–20%). In terms of mechanism, metastatic tumors tend to be more circumscribed than infiltrating primary tumors, which may explain the lower frequency of seizures in metastatic patients.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Epilepsy on the Quality of Life of Patients with Brain Tumors

Krajewski

Wójcik

Harat

et al. 2021

IJERPH

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Epilepsy is a common consequence of brain tumors, occurring in 35 to 75% of cases. Here we evaluated the influence of epilepsy on the quality of life (QoL) of patients with malignant brain tumors (primary and metastatic) and assessed which areas of function are most affected by epilepsy and brain tumors. Sixty patients undergoing brain tumor surgery at the Neurosurgery Clinic of the 10th Military Research Hospital, Bydgoszcz, Poland (30 with epilepsy and 30 without epilepsy) were studied. Relationships between categorical variables were determined with Pearson’s chi-squared test, while continuous data were analyzed with the Mann-Whitney U-test. A p value < 0.05 was considered statistically significant. A multiple regression model was used for multivariate analysis of QoL. Patients with epilepsy more frequently reported memory disorders as a problem in their daily life. There were trends towards greater impairments in social, professional, and family life, sports and recreational activities, and daily physical activities in brain tumor patients with epilepsy rather than those without epilepsy. Higher frequency and generalized seizures significantly and adversely influenced the ability of patients to leave home and drive vehicles, but a proportion of patients with frequent, generalized seizures continued to drive regardless. Patients with generalized seizures considered the adverse effects of taking medicines as significantly disruptive. Memory disorders significantly affect the QoL of patients with epilepsy, and the importance of stopping driving must be emphasized by all healthcare professionals.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of Epilepsy on the Quality of Life of Patients with Brain Tumors

Krajewski

Wójcik

Harat

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Compared with whole-brain radiation therapy (WBRT), SRS carries a lower risk of seizure, ranging from 5% to 13%. [31][32][33][34][35] No clear guidelines for AED administration in this population currently exist, leading to heterogeneity in provider practice. Many clinicians take a conservative approach; a recent survey of 500 radiation oncologists found that 79% of respondents stated that they rarely or never prescribe anticonvulsants, and less than 10% usually or always recommend AED usage.…”

Section: Primary Preventionmentioning

confidence: 99%

“…36 Some providers may recommend AEDs to select patients based on perceived seizure risk; for instance, there is a suspected higher seizure risk in patients with lesions in eloquent cortex. 31,33,37 Nevertheless, there is no evidence at this time to support the use of prophylactic AEDs before SRS.…”

Section: Primary Preventionmentioning

confidence: 99%