“…The bright yellow tryptophan alkaloid aplysinopsin (80), first reported in 1977 [77] from a Great Australian Bight sponge of the genus Thorecta sp., heralded the discovery of a great many related and uniquely sponge-derived natural products, including from the gen-era Verongia, Dercitus, Smenospongia, Dictyoceratida, Aplysina, Hyrtios, and Thorectandra [78]. Many examples of the aplysinopsin family of natural products were reported to exhibit prominent biological properties ranging across antimicrobial, antiviral, antimalarial, anticancer, anti-cholinesterase, and anti-depressant activity [79]. Indeed, some 36 years after first being reported from a northern Australian sponge, we returned to the aplysinopsin scaffold and, in 2013 [80], reported on a series of new analogues from the southern Australia sponge Ianthella cf.…”