An overview of autoantibodies in rheumatoid arthritis

Delft, Myrthe A. M. van; Huizinga, Tom W J

doi:10.1016/j.jaut.2019.102392

Cited by 239 publications

(153 citation statements)

References 154 publications

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“…RF is likely to exert its pathogenic properties via the creation of immune complexes. Then, proinflammatory cytokines, such as TNF- α and IL-1 β , are stimulated and contributing in chronic inflammation and bone destruction [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Combinatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant-Induced Arthritis in Wistar Rats: Roles of IL-1β, IL-4, Nrf-2, and Oxidative Stress

Ahmed

Fahim

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Rheumatoid arthritis (RA) is a disorder triggered by autoimmune reactions and related with chronic inflammation and severe disability. Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) have shown a hopeful immunomodulatory effect towards repairing cartilage and restoring joint function. Additionally, indomethacin (IMC), a nonsteroidal compound, has been considered as a potent therapeutic agent that exhibits significant antipyretic properties and analgesic effects. The target of the current research is to assess the antiarthritic efficacy of BM-MSCs (106 cells/rat at 1, 6, 12 and 18 days) and IMC (2 mg/kg body weight/day for 3 weeks) either alone or concurrently administered against complete Freund’s adjuvant-induced arthritic rats. Changes in paw volume, body weight, gross lesions, and antioxidant defense system, as well as oxidative stress, were assessed. The Th1 cytokine (IL-1β) serum level and Th2 cytokine (IL-4) and Nrf-2 ankle joint expression were detected. In comparison to normal rats, it was found that the CFA-induced arthritic rats exhibited significant leukocytosis and increase in paw volume, LPO level, RF, and IL-1β serum levels. In parallel, arthritic rats that received BM-MSCs and/or IMC efficiently exhibited decrease in paw edema, leukocytosis, and enhancement in the antioxidant enzymatic levels of SOD, GPx, GST, and GSH in serum besides upregulation of Nrf-2 and anti-inflammatory IL-4 expression levels in the ankle articular joint. Likewise, these analyses were more evidenced by the histopathological sections and histological score. The data also revealed that the combined administration of BM-MSC and IMC was more potent in suppressing inflammation and enhancing the anti-inflammatory pathway than each agent alone. Thus, it can be concluded that the combined therapy with BM-MSC and IMC may be used as a promising therapeutic choice after assessing their efficacy and safety in human beings with RA, and the antiarthritic effects may be mediated via modulatory effects on Th1/Th2 cytokines, ozidative stress, and Nrf-2.

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Section: Discussionmentioning

confidence: 99%

Combinatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant-Induced Arthritis in Wistar Rats: Roles of IL-1β, IL-4, Nrf-2, and Oxidative Stress

Ahmed

Fahim

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Despite the role of these auto-antibodies being still unclear, multiple studies have shown that seropositive patients are likely to develop a more severe disease when compared to seronegative patients [ 44 , 45 ]. Serum rheumatoid factor (RF) and anti-CCP are currently used as biomarkers for the diagnosis of RA [ 6 ]. These antibodies (Abs) appear many years prior to RA onset, during the so-called “pre-clinical” course of the disease [ 46 , 47 ].…”

Section: Ra Immunopathogenesismentioning

confidence: 99%

“…RA usually affects hands, feet, and wrists, leading to progressive bone and cartilage damage, resulting in deformities, joints loss of function, and reduced independence in performing daily activities [ 4 , 5 ]. RA clinical manifestations are usually not confined to musculoskeletal system, but also involve cardiovascular system, kidneys, lungs, liver and skin [ 6 ]. RA onset is usually insidious.…”

Section: Introductionmentioning

confidence: 99%

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

Jasemi

Uras

et al. 2020

Microorganisms

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Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic erosive polyarthritis. A complex interaction between a favorable genetic background, and the presence of a specific immune response against a broad-spectrum of environmental factors seems to play a role in determining susceptibility to RA. Among different pathogens, mycobacteria (including Mycobacterium avium subspecies paratuberculosis, MAP), and Epstein–Barr virus (EBV), have extensively been proposed to promote specific cellular and humoral response in susceptible individuals, by activating pathways linked to RA development. In this review, we discuss the available experimental and clinical evidence on the interplay between mycobacterial and EBV infections, and the development of the immune dysregulation in RA.

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“…ACPA (anti-citrullinated protein antibody) and RF (rheumatoid factor) are two widely accepted autoantibodies used in clinical practice as biologic markers of RA [6]. Nonetheless, neither of these two markers has sufficient specificity or sensitivity for effective diagnosis of all RA patients, and neither autoantibody allows classification of patient subpopulations or patient outcome [6]. Recently, CTHRC1 has emerged as a new biomarker that may contribute to improved RA diagnosis and assessment of disease activity [7,8].…”

Section: Introductionmentioning

confidence: 99%

The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis

Myngbay

Manarbek

Ludbrook

et al. 2021

IJMS

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Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available options for patient treatment. The Collagen Triple Helix Repeat Containing 1 protein (CTHRC1) may have an important role as a biomarker for rheumatoid arthritis, as CTHRC1 protein concentration is significantly elevated in the peripheral blood of rheumatoid arthritis patients compared to osteoarthritis (OA) patients and healthy individuals. CTHRC1 is a secreted glycoprotein that promotes cell migration and has been implicated in arterial tissue-repair processes. Furthermore, high CTHRC1 expression is observed in many types of cancer and is associated with cancer metastasis to the bone and poor patient prognosis. However, the function of CTHRC1 in RA is still largely undefined. The aim of this review is to summarize recent findings on the role of CTHRC1 as a potential biomarker and pathogenic driver of RA progression. We will discuss emerging evidence linking CTHRC1 to the pathogenic behavior of fibroblast-like synoviocytes and to cartilage and bone erosion through modulation of the balance between bone resorption and repair.

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An overview of autoantibodies in rheumatoid arthritis

Cited by 239 publications

References 154 publications

Combinatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant-Induced Arthritis in Wistar Rats: Roles of IL-1β, IL-4, Nrf-2, and Oxidative Stress

Combinatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin on Adjuvant-Induced Arthritis in Wistar Rats: Roles of IL-1β, IL-4, Nrf-2, and Oxidative Stress

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria

The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis

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