An overview of biological research on hypoxia-inducible factors (HIFs)

Liu, Zhe; Wu, Zhenqiang; Fan, Yuxin; Fang, Yifan

doi:10.5603/ep.a2020.0064

Cited by 18 publications

(9 citation statements)

References 89 publications

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“…With the uncontrolled growth of tumour cells and abnormalities in tumour microcirculation (9), hypoxia is an obvious feature of the TME, which is positively associated with tumour growth, angiogenesis, resistance to apoptosis and chemotherapy, and tumour metastasis (10). Hypoxia-inducible factors (HIFs) constitute a family of transcription factors that are involved in the regulation of the cellular response to hypoxic stress (11)and include three members: HIF-1 (12), HIF-2 (13), and HIF-3 (14).…”

Section: Introductionmentioning

confidence: 99%

HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies

Wang

et al. 2021

Front. Oncol.

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Ovarian cancer is the eighth most commonly diagnosed cancer among women worldwide. Even with the development of novel drugs, nearly one-half of the patients with ovarian cancer die within five years of diagnosis. These situations indicate the need for novel therapeutic agents for ovarian cancer. Increasing evidence has shown that hypoxia-inducible factor-1α(HIF-1α) plays an important role in promoting malignant cell chemoresistance, tumour metastasis, angiogenesis, immunosuppression and intercellular interactions. The unique microenvironment, crosstalk and/or interaction between cells and other characteristics of ovarian cancer can influence therapeutic efficiency or promote the disease progression. Inhibition of the expression or activity of HIF-1α can directly or indirectly enhance the therapeutic responsiveness of tumour cells. Therefore, it is reasonable to consider HIF-1α as a potential therapeutic target for ovarian cancer. In this paper, we summarize the latest research on the role of HIF-1α and molecules which can inhibit HIF-1α expression directly or indirectly in ovarian cancer, and drug clinical trials about the HIF-1α inhibitors in ovarian cancer or other solid malignant tumours.

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Section: Introductionmentioning

confidence: 99%

HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies

Wang

et al. 2021

Front. Oncol.

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“…Changes in O 2 levels typically converge to the activation of a specific transcriptional response aimed at counterbalancing this dysregulation. It is well known that the central elements of the cytoplasmic O 2 sensor pool are the Hypoxia-Inducible Factors (HIFs) (Liu et al, 2020). The human genome encodes three different HIF subtypes: HIF-1, HIF-2 and HIF-3, which are heterodimers composed of a functional α subunit and a stably expressed β subunit (Dengler et al, 2014).…”

Section: Cytoplasmic O 2 Sensors: the Role Of Hif-1mentioning

confidence: 99%

Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation

Rey

Messa

Maghraby

et al. 2023

Antioxidants & Redox Signaling

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Significance: Oxygen sensing is the fundamental process through which organisms respond to changes in oxygen levels. Complex networks exist allowing the maintenance of oxygen levels through the perception, capture, binding, transport and delivery of molecular oxygen. The brain extreme sensitivity to oxygen balance makes the dysregulation of related processes crucial players in the pathogenesis of neurodegenerative diseases. Here we wish to review the most relevant advances in oxygen sensing in relation to Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis. Recent Advances: Over the years, it has been clarified that most neurodegenerative diseases share common pathways, a great number of which are in relation to oxygen imbalance. These include hypoxia, hyperoxia, ROS production, metabolism of metals, protein misfolding and neuroinflammation. Critical Issues: There is still a gap in knowledge concerning how oxygen sensing plays a role in the above indicated neurodegenerations. Specifically, oxygen concentrations are perceived in body sites which are not limited to the brain, but primarily reside in other organs. Moreover, the mechanisms of oxygen sensing, gene expression and signal transduction seem to correlate with neurodegeneration but many aspects are mechanistically still unexplained. Future Directions: Future studies should focus on the precise characterization of oxygen levels disruption and oxygen sensing mechanisms in neurodegenerative diseases.Moreover, advances need to be made also concerning the techniques used to assess oxygen sensing dysfunctions in these diseases. There is also the need to develop innovative therapies targeting this precise mechanism rather than its secondary effects, as early intervention is necessary.

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“…3,4 Hypoxia-inducible factors (HIFs) constitute a family of transcription factors that are involved in the regulation of the cellular response to hypoxic stress. 5,6 HIF-1 alpha is know as potential tumor marker plays an important role in transcriptional responses including the induction of genes involved in the induction of genes relevant to tumor development, such as angiogenesis, energy/glucose metabolism, cell development, metastasis and apoptosis. 4 This study was conducted to investigate the association of the HIF-1α with stage,hystological type of ephitelial ovarian cancer (EOC).…”

Section: Introductionmentioning

confidence: 99%

Association Hypoxia Inducible Factors-1 Alpha (HIF-1 α) Levels and Epithelial Ovarian Cancer (EOC)

Asis

2023

Obgynia

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Objective: This study was conduct to investigate the association of the HIF-1α with stage,hystological type of ephitelial ovarian cancer (EOC). Methods: This study is an observational study with a cross-sectional design on 72 women diagnosed with epithelial ovarian carcinoma who underwent surgical staging in a period of 2017 to 2019 in Wahidin Sudirohusodo Hospital. Measurement of HIF1a concentration was performed and further categorized into weak, moderate and strong and then analyzed with age, parity, history of abortion, ascites, type of histopathology, cancer stage and CA-125 serum level. Result: There’s a significant relationship between HIF-1a expression and stage (p<0.05), where moderate expression of HIF1a was the most dominant with a total of 32 (44.4%) people. Moderate-to-strong expression of HIF1a was found more in patients with epithelial ovarian carcinoma than weak-to-negative HIF1a expression. More patients with stage III-IV ovarian carcinoma were found with moderate-to-strong HIF1a expression (51 people). Conclusion: HIF1a expression was found to be increased along with the progression of epithelial ovarian cancer stage where positive HIF1a expression was found more in patients with stage III/IV compared to stage I/II. Hubungan Antara Kadar Hypoxia Inducible Factors-1 Alpha (HIF-1 α) dengan Karsinoma Ovarium Tipe Epitelial Abstrak Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara kadar HIF-1 alpha dan karsinoma ovarium tipe epithelial Metode: Penelitian ini menggunakan desain case-control pada 72 perempuan dengan karsinoma ovarium tipe epitelial yang telah menjalani surgical staging selama tahun 2017 hingga 2019 di RS Wahidin Sudirohusodo. Peneliti mengukur kadar HIF1a dan mengkategorikan dalam negatif, lemah, sedang, dan kuat serta menilai hubungannya dengan usia, paritas, riwayat abortus, ascites, jenis histologi, stadium kanker ovarium, dan kadar CA-125. Hasil: Terdapat hubungan antara stadium dan ekspresi HIF1a (p<0.05). HIF1a dengan ekspresi-sedang didapatkan paling banyak yaitu 32 (44.4%) orang. Lebih banyak ditemukan ekspresi HIF1a sedang-kuat pada pasien karsinoma ovarium tipe epithelial dibandingkan ekspresi HIF1a negatif-lemah. Pasien karsinoma ovarium stadium 3-4 lebih banyak ditemukan dengan ekspresi HIF1a sedang-kuat (51 orang). Kesimpulan: Terdapat hubungan yang bermakna antara ekspresi HIF1a dan stadium kanker ovarium tipe epitelial yaitu ekspresi positif HIF1a lebih banyak ditemukan pada pasien dengan stadium III/IV dibandingkan stadium I/II. Kata kunci: Karsinoma ovarium tipe epitelial, Hypoxia Inducible Factor 1 alpha (HIF1a), stadium kanker

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An overview of biological research on hypoxia-inducible factors (HIFs)

Cited by 18 publications

References 89 publications

HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies

HIF-1α Is a Rational Target for Future Ovarian Cancer Therapies

Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation

Association Hypoxia Inducible Factors-1 Alpha (HIF-1 α) Levels and Epithelial Ovarian Cancer (EOC)

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