2021
DOI: 10.3390/microorganisms9122457
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An Overview of Bioprocesses Employing Specifically Selected Microbial Catalysts for γ-Aminobutyric Acid Production

Abstract: Gamma-aminobutyric acid (GABA) is an important chemical compound in the human brain. GABA acts as an inhibitory neurotransmitter by inducing hyperpolarization of cellular membranes. Usually, this pharmaceutically important compound is synthesized using a chemical process, but in this short overview we have only analysed microbial processes, which have been studied for the biosynthesis of this commercially important compound. The content of this article includes the following summarised information: the search … Show more

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Cited by 30 publications
(24 citation statements)
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“…For instance, L. plantarum could need l-Glu supplementation to metabolise it and enhance the bacteria growth 54 . Likewise, l-Glu could also be required to activate the secondary metabolism to produce postbiotic compounds such as GABA 55 or plantaricin 56 . Furthermore, l-Glu is usually supplemented directly into the fermentation media of L. plantarum strains due to this amino acid is the GABA precursor 57 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…For instance, L. plantarum could need l-Glu supplementation to metabolise it and enhance the bacteria growth 54 . Likewise, l-Glu could also be required to activate the secondary metabolism to produce postbiotic compounds such as GABA 55 or plantaricin 56 . Furthermore, l-Glu is usually supplemented directly into the fermentation media of L. plantarum strains due to this amino acid is the GABA precursor 57 .…”
Section: Discussionmentioning
confidence: 99%
“…In the same way, MSG has been used in several studies to enhance GABA synthesis [58][59][60] . However, the MSG concentration should be optimised for each strain due to an excessive MSG concentration could be toxic and suppress the GAD enzyme 55 . In this investigation, increasing the concentration of MSG from 100 to 500 mM significantly enhanced GABA synthesis, but a reduction in GABA production was observed by supplying 550 mM of MSG (Table 2).…”
Section: Discussionmentioning
confidence: 99%
“…Studies have investigated the potential of probiotics in the support of social anxiety, other mental-health-related conditions, and central GABA receptor expression [80,81]. The effects of synbiotic administration on stress-related parameters have been studied [82].…”
Section: Microbiome-gut-brain Axismentioning
confidence: 99%
“…Enzymes have been manipulated to improve their quality of biotransformation and bioconversion to speed up the biochemical reactions for their suitability and sustainability for industrial applications [4]. If a reaction can be completed using intercellular or extracellular enzymes synthesised by specific microbes, the process of biotransformation would be economical for the large-scale synthesis of specialty molecules of industrial importance, such as flavours and aromas for the food industry and optically pure compounds for the pharmaceutical industry [4,5]. Researchers have designed effective cell-factories, incorporating enzymes as well as actively growing whole microbial cells, together in one biocatalyst entity [6][7][8].…”
Section: Hydrolase Enzymesmentioning
confidence: 99%
“…Among extremophiles, microorganisms living in cold or hot environments have become a source for the production of enzymes with specific characteristics, which could be active in conditions of lower or higher temperatures, as they would be needed to catalyse different biotransformation reactions of varied temperature requirements [5]. The use of enzymes at low temperatures has economical potential for industrial processes through energy savings by lowering the reaction temperature without the deactivation of enzyme activity.…”
Section: Introductionmentioning
confidence: 99%