An overview of circulating and urinary biomarkers capable of predicting the transition of acute kidney injury to chronic kidney disease

Berezin, Alexander E.; Berezina, Tetiana A.; Hoppe, Uta C.; Lichtenauer, Michael; Berezin, Alexander A.

doi:10.1080/14737159.2024.2379355

Expert Review of Molecular Diagnostics

2024

DOI: 10.1080/14737159.2024.2379355

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An overview of circulating and urinary biomarkers capable of predicting the transition of acute kidney injury to chronic kidney disease

Alexander E. Berezin,

Tetiana A. Berezina,

Uta C. Hoppe

et al.

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2024

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Biomarkers of Acute Kidney Injury of Blood Serum in Patients With Thermal Skin Burns

Konovalova,

Tsepelev

2024

jour

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The aim: to evaluate the dynamics of changes in the level of biomarkers of acute kidney injury – lipocalin and cystatin C in blood serum in patients with thermal skin burns.Materials and methods. The study included 74 patients with thermal skin burns of I-III degree with a skin lesion area of more than 25%, of which at least 15% are deep burns. Serum creatinine levels were determined using the kinetic Jaffe method. Lidocaine and cystatin C concentrations were studied by multiplex analysis on a flow cytofluorimeter.Results. It was found that the concentration of cystatin C in the blood serum during burn shock increases by 1,9 times, with burn toxemia and septicotoxemia - by 1,5 times in relation to the control group. The level of lipocalin in the blood serum of patients with thermal skin burns during the shock period increases by 5,5 times compared to the control group. During the period of burn toxemia and septicotoxemia, lidocaine concentration remained at a high level and exceeded the control values by 4,4 and 3,6 times, respectively.Conclusion. Lipocaine and cystatin C can be considered as early biomarkers of acute kidney injury in patients with thermal skin burns.

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Biomarkers of Acute Kidney Injury of Blood Serum in Patients With Thermal Skin Burns

Konovalova,

Tsepelev

2024

jour

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An overview of circulating and urinary biomarkers capable of predicting the transition of acute kidney injury to chronic kidney disease

Cited by 1 publication

References 244 publications

Biomarkers of Acute Kidney Injury of Blood Serum in Patients With Thermal Skin Burns

Biomarkers of Acute Kidney Injury of Blood Serum in Patients With Thermal Skin Burns

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