An overview of DNA/RNA-based monitoring tools and biosensors: Benefits and applications in the environmental toxicology

Hong, Ka Lok

doi:10.1016/b978-0-12-814679-8.00005-4

Cited by 5 publications

(4 citation statements)

References 122 publications

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“…Numerous studies have been reported on DNA sensing techniques [ 51 , 52 ]; even when we focus on the studies on ssDNA targets, there is a large number of literature. We here mention two active directions to attain new DNA biosensors.…”

Section: Discussionmentioning

confidence: 99%

“…However, to our knowledge, practical electrochemical biosensors with extremely low LOD have not been established. The other intends to exploit aptamers [ 52 ]; the studies on aptamer biosensors are rapidly enlarging the targets in these five years. DNA aptamers are designed to have a particular function and can amplified electrochemical or FL signals; therefore, they have potential to contribute to highly sensitive sensing for ssDNA though we have not found any literature exhibiting such results.…”

Section: Discussionmentioning

confidence: 99%

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High-Sensitivity High-Throughput Detection of Nucleic Acid Targets on Metasurface Fluorescence Biosensors

Iwanaga

2021

Biosensors

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Worldwide infection disease due to SARS-CoV-2 is tremendously affecting our daily lives. High-throughput detection methods for nucleic acids are emergently desired. Here, we show high-sensitivity and high-throughput metasurface fluorescence biosensors that are applicable for nucleic acid targets. The all-dielectric metasurface biosensors comprise silicon-on-insulator nanorod array and have prominent electromagnetic resonances enhancing fluorescence emission. For proof-of-concept experiment on the metasurface biosensors, we have conducted fluorescence detection of single-strand oligoDNAs, which model the partial sequences of SARS-CoV-2 RNA indicated by national infection institutes, and succeeded in the high-throughput detection at low concentrations on the order of 100 amol/mL without any amplification technique. As a direct detection method, the metasurface fluorescence biosensors exhibit high performance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High-Sensitivity High-Throughput Detection of Nucleic Acid Targets on Metasurface Fluorescence Biosensors

Iwanaga

2021

Biosensors

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“…The DNA and RNA has a high chemical/thermal stability and good variation. DNA and RNA were used as specific recognizing elements for bioreceptors and biosensors (Hong et al, 2019). Amperometric DNA-or RNA-based biosensors have been developed for the detection of various elements (Blair and Corrigan, 2019).…”

Section: Proteinsmentioning

confidence: 99%

Modern nanobiotechnologies for efficient detection and remediation of mercury

Gaur

Yadav

Kushwah

et al. 2021

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Purpose This information will be useful in the selection of materials and technology for the detection and removal of mercury ions at a low cost and with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity. Design/methodology/approach Different nano- and bio-materials allowed for the development of a variety of biosensors – colorimetric, chemiluminescent, electrochemical, whole-cell and aptasensors – are described. The materials used for their development also make it possible to use them in removing heavy metals, which are toxic contaminants, from environmental water samples. Findings This review focuses on different technologies, tools and materials for mercury (heavy metals) detection and remediation to environmental samples. Originality/value This review gives up-to-date and systemic information on modern nanotechnology methods for heavy metal detection. Different recognition molecules and nanomaterials have been discussed for remediation to water samples. The present review may provide valuable information to researchers regarding novel mercury ions detection sensors and encourage them for further research/development.

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“…Because DNA molecules are generally more resistant to nuclease degradation than RNA molecules in vitro, single-stranded DNA (ssDNA) aptamers have received a higher amount of attention in their in vitro diagnostic and biosensing applications [ 10 , 11 ]. The process for identifying aptamers has been extensively reviewed previously [ 8 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in the Identification of Aptamers Against Bacterial Origins and Their Diagnostic Applications

Trunzo

Hong

2020

IJMS

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Aptamers have gained an increasing role as the molecular recognition element (MRE) in diagnostic assay development, since their first conception thirty years ago. The process to screen for nucleic acid-based binding elements (aptamers) was first described in 1990 by the Gold Laboratory. In the last three decades, many aptamers have been identified for a wide array of targets. In particular, the number of reports on investigating single-stranded DNA (ssDNA) aptamer applications in biosensing and diagnostic platforms have increased significantly in recent years. This review article summarizes the recent (2015 to 2020) progress of ssDNA aptamer research on bacteria, proteins, and lipids of bacterial origins that have implications for human infections. The basic process of aptamer selection, the principles of aptamer-based biosensors, and future perspectives will also be discussed.

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An overview of DNA/RNA-based monitoring tools and biosensors: Benefits and applications in the environmental toxicology

Cited by 5 publications

References 122 publications

High-Sensitivity High-Throughput Detection of Nucleic Acid Targets on Metasurface Fluorescence Biosensors

High-Sensitivity High-Throughput Detection of Nucleic Acid Targets on Metasurface Fluorescence Biosensors

Modern nanobiotechnologies for efficient detection and remediation of mercury

Recent Progress in the Identification of Aptamers Against Bacterial Origins and Their Diagnostic Applications

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