An Overview of Effects on Reproductive Physiology of Melatonin

Gelen, Volkan; Şengül, Emin; Kükürt, Abdulsamed

doi:10.5772/intechopen.108101

Cited by 3 publications

(2 citation statements)

References 116 publications

(105 reference statements)

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“…Physiologically low levels of ROS play a role as an important regulator of various signal transduction pathways in folliculogenesis, oogenesis, embryogenesis, and pregnancy [5]. High levels of ROS, caused by increased production of oxidant species and/or decreased effectiveness of the antioxidant system, lead to oxidative stress [14,[34][35][36][37][38][39]. Therefore, ovarian oxidative stress models will make important contributions to the understanding of these relationships, since the relationships between oxidative stress induced by ROS and the female reproductive system are not fully understood [40].…”

Section: Possible Effects Of Astaxanthin On Ovariesmentioning

confidence: 99%

The Use of Astaxanthin as a Natural Antioxidant on Ovarian Damage

Kükürt¹,

Karapehlivan²,

Gelen³

2023

Animal Models and Experimental Research in Medicine

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The ovaries are defined as the organs that secrete sex hormones and ensure the formation of the ovum in females. The proper functioning of the physiological functions of the ovaries is very important for the health of both the body and the female reproductive system. Reactive oxygen species are produced as byproducts of the normal physiological metabolism of the ovary. Antioxidants are among the factors that work to maintain the balance between the production and excretion of reactive oxygen species. Since the deterioration in the antioxidant system can cause pathological results, antioxidant supplementation is considered a possible strategy for the treatment of reproductive diseases by keeping oxidative stress under control. This chapter provides information about the use of astaxanthin as a natural antioxidant against ovarian damage.

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Section: Possible Effects Of Astaxanthin On Ovariesmentioning

confidence: 99%

The Use of Astaxanthin as a Natural Antioxidant on Ovarian Damage

Kükürt¹,

Karapehlivan²,

Gelen³

2023

Animal Models and Experimental Research in Medicine

Self Cite

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“…The consumption of antioxidant-rich foods and supplements has been associated with numerous health benefits. Antioxidants can help mitigate ROS and protect against oxidative stress [24][25][26][27][28].…”

Section: Association Of Paraoxonase 1 With Oxidative Stressmentioning

confidence: 99%

Paraoxonase 1 in Cattle Health and Disease

Kükürt¹,

Gelen²

2023

Veterinary Medicine and Science

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Paraoxonase is a family of enzymes with diverse biological functions. This study investigates the role and effects of the paraoxonase enzyme, particularly in relation to cattle health and disease. The findings reveal that the paraoxonase enzyme mitigates oxidative stress, regulates the immune system, preserves liver function, and exerts other biological effects in cattle. Moreover, certain genetic variations associated with the paraoxonase enzyme may be linked to health issues, such as cattle diseases. Therefore, further research aimed at comprehending the relationship between the paraoxonase enzyme and cattle health may assist in the development of novel treatment and prevention strategies in future cattle breeding and veterinary applications.

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Short-Term Treatment of Melatonin Improves the Expression of Cell Adhesion Molecules in the Testis of the Mouse Cryptorchidism Model

Wanta,

Noguchi,

Sugawara

et al. 2024

J Histochem Cytochem.

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Melatonin plays a major role in regulating the sleep-wake cycle and enhancing testosterone production. We investigated the short-term effects of melatonin treatment for 14 consecutive days in the cryptorchidism model. We categorized experimental mice into Sham (S), Orchiopexy (O), Melatonin (Mel), and Orchiopexy + Melatonin (OMel) groups. Surgery involved inducing cryptorchidism in the left testis for seven days, followed by orchiopexy. The Mel group’s testes did not descend, but they received melatonin injections after seven days of cryptorchidism. The OMel group underwent both orchiopexy and melatonin treatment. Both O and Mel groups exhibited decreased sperm and round-headed sperm in the epididymis. Significant increases were observed in the numbers of giant cells and negative Nectin-3 cells at p-value<0.05. The pattern of Cadm1 expression changed, and Nectin-2 and Nectin-3 co-expression was lacking in abnormal spermatids. Sertoli cell cytoplasm in both O and Mel groups exhibited autophagosomes and multivesicular bodies, which correlated with increased cyclooxygenase-2 expression. However, Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cell numbers increased significantly in all treatment groups compared to the S group. Our study found that the combination of orchiopexy and melatonin positively influenced the expression of cell adhesion molecules (Cadm1, Nectin-2, and Nectin-3) involved in spermatogenesis, while reducing giant cells, autophagosomes, and apoptosis.

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An Overview of Effects on Reproductive Physiology of Melatonin

Cited by 3 publications

References 116 publications

The Use of Astaxanthin as a Natural Antioxidant on Ovarian Damage

The Use of Astaxanthin as a Natural Antioxidant on Ovarian Damage

Paraoxonase 1 in Cattle Health and Disease

Short-Term Treatment of Melatonin Improves the Expression of Cell Adhesion Molecules in the Testis of the Mouse Cryptorchidism Model

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