An overview of electrospun membranes loaded with bioactive molecules for improving the wound healing process

Miguel, Sónia P.; Sequeira, Rosa S.; Moreira, André F.; Cabral, Cátia S.D.; Mendonça, António; Ferreira, Paula; Correia, Ilídio J.

doi:10.1016/j.ejpb.2019.03.010

Cited by 146 publications

(92 citation statements)

References 141 publications

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“…Ninety percent porosity and a pore size in the range of 10-100 µm seem to be the most suitable for neuron growth. Scaffolds characterized by 85-90% porosity may be obtained by the electrospinning technique [99]. Such porosity is reported as supporting cellular migration and controlled diffusion of cells, metabolites, and medium, being important for cells organization, differentiation, and survival [100,101].…”

Section: Scaffolds: Stimuli Responsive (Piezoelectric) Vs Passivementioning

confidence: 99%

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

2020

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Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities, which still lacks an effective treatment. Tissue engineering in the post-injury brain represents a promising option for cellular replacement and rescue, providing a cell scaffold for either transplanted or resident cells. Tissue engineering relies on scaffolds for supporting cell differentiation and growth with recent emphasis on stimuli responsive scaffolds, sometimes called smart scaffolds. One of the representatives of this material group is piezoelectric scaffolds, being able to generate electrical charges under mechanical stimulation, which creates a real prospect for using such scaffolds in non-invasive therapy of neural tissue. This paper summarizes the recent knowledge on piezoelectric materials used for tissue engineering, especially neural tissue engineering. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges, and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and serves as a starting point for novel research pathways in the most relevant and challenging open questions.

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Section: Scaffolds: Stimuli Responsive (Piezoelectric) Vs Passivementioning

confidence: 99%

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

2020

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“…The EOs, and their respective components, hydrophobic character promote the partition of the lipids that are present in the bacteria cell membrane, increasing their permeability and, consequently, leading to the membrane rupture and leakage of intracellular content, ultimately inducing cell death. Therefore, EOs loaded dressings may act as powerful tools to circumvent bacteria multi-drug resistance in infected wounds [209]. In fact, studies have already shown the improved synergistic effect of the oregano EO with CA-based nanofibers against S. aureus, E. coli and the yeast Candida albicans (C. albicans), as a result of the potent antimicrobial character of the oregano oil molecular components carvacol and thymol [67].…”

Section: Natural Extractsmentioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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“…Nanofibers have a high surface to volume ratio and porosity, which can increase drug loading, transport, and cell attachment [196,200,202]. Nanofiber scaffolds mimic the structure of the extracellular matrix, which can help with cell proliferation, thereby promoting re-epithelialization and wound closure [1,203,204]. The porosity of nanofiber matrices aids the adsorption of wound exudate, the exchange of nutrients, and provides coverage against bacterial attachment [204,205].…”

Section: Nanoscale Materialsmentioning

confidence: 99%

“…Nanofiber scaffolds mimic the structure of the extracellular matrix, which can help with cell proliferation, thereby promoting re-epithelialization and wound closure [1,203,204]. The porosity of nanofiber matrices aids the adsorption of wound exudate, the exchange of nutrients, and provides coverage against bacterial attachment [204,205]. Nanofibers can be synthesized from a wide range of material, including biodegradable and non-biodegradable polymers, naturally occurring polymers, and composite materials [203].…”

Section: Nanoscale Materialsmentioning

confidence: 99%

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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An overview of electrospun membranes loaded with bioactive molecules for improving the wound healing process

Cited by 146 publications

References 141 publications

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

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