The two-stage Hybrid flow shop (HFS) scheduling is characterized n jobs m machines with two-stages in series. The essential complexities of the problem need to solve the hybrid flow shop scheduling using meta-heuristics. The paper addresses two-stage hybrid flow shop scheduling problems to minimize the makespan time with the batch size of 100 using Genetic Algorithm (GA) and Simulated Annealing algorithm (SA). The computational results observed that the GA algorithm is finding out good quality solutions than SA with lesser computational time.