2023
DOI: 10.3390/vaccines11061102
|View full text |Cite
|
Sign up to set email alerts
|

An Overview of Indian Biomedical Research on the Chikungunya Virus with Particular Reference to Its Vaccine, an Unmet Medical Need

Abstract: Chikungunya virus (CHIKV) is an infectious agent spread by mosquitos, that has engendered endemic or epidemic outbreaks of Chikungunya fever (CHIKF) in Africa, South-East Asia, America, and a few European countries. Like most tropical infections, CHIKV is frequently misdiagnosed, underreported, and underestimated; it primarily affects areas with limited resources, like developing nations. Due to its high transmission rate and lack of a preventive vaccine or effective treatments, this virus poses a serious thre… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
3
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 210 publications
0
3
0
Order By: Relevance
“…Bharat Biotech has developed an inactivated and highly purified CHIKV immunogenic formulation (BBV87) for use as a vaccine. Phase 1 clinical trials successfully elicited an immunological response against CHIKV [ 24 ].
Fig.
…”
Section: Emerging Disease and Its Vaccinementioning
confidence: 99%
“…Bharat Biotech has developed an inactivated and highly purified CHIKV immunogenic formulation (BBV87) for use as a vaccine. Phase 1 clinical trials successfully elicited an immunological response against CHIKV [ 24 ].
Fig.
…”
Section: Emerging Disease and Its Vaccinementioning
confidence: 99%
“…The RNA genome of CHIKV encodes four non-structural proteins (nsP1 to nsP4) that are required for virus replication and three structural proteins (Capsid, E1 and E2) together with two small cleavage products (E3 and 6K). The E1 and E2 glycoproteins regulate the entry of viruses into host cells; E1 is involved in the fusion of the virus with the cell membrane, whereas E2 interacts with the receptors on cells and aids in cell attachment [4,7,8]. The E2 glycoprotein has been identified as the primary target for the anti-CHIKV antibody response throughout the illness [3].…”
Section: Introductionmentioning
confidence: 99%
“…With increasing seroprevalence data, this study contributes to our understanding of the disease's dynamics post-vaccination [13]. In the context of the Chikungunya virus, one article discusses the outbreak history of CHIKV in India and emphasizes the subsequent necessity to advance knowledge for effective treatment and preventive strategies [14].…”
mentioning
confidence: 99%