“…Several recent works have proposed a systems perspective on process safety (e.g., [3,20,22,36]) which encourages engineers to consider process incidents as events that occur due to a migration of the process state, over time, to conditions at which an accident may occur (this may be applicable, for example, in the case of reactor thermal runaway). Traditional approaches to process safety like process design modifications neglect important aspects impacting process operational safety, such as multivariable interactions of process components and variables, limited control system authority due to limitations on the capacity of control actuators, and the manner in which the safety or relief system response may impact the effectiveness of the process control system [20,40]. Accounting for such aspects in the control and safety system designs can be crucial to ensuring process operational safety.…”