The process of technology transfer is complex and involves a series of factors and variables. Within this process, it is common that transferor and transferee might face several barriers. Furthermore, processes involving innovation and technology transfer must consider the impacts for the sustainable development. Taking these aspects into account, this paper aims to identify the barriers and opportunities in technology transfer oriented to sustainable development. To reach this goal, a systematic review of literature was carried out using the methodology Methodi Ordinatio. A portfolio composed of 107 scientific articles was built. The results demonstrate the main barriers, among which we can mention unavailability of financial resources or subsidies to obtain or implement a certain technology, and bureaucracy to obtain these resources. On the other hand, some opportunities can also be found, like Clean Development Mechanism and policies and regulations that favour the adoption and diffusion of clean technologies. Thus, this paper contributes to the academy by exploring the interconnections of Technology Transfer and Sustainable Development in the literature. This paper also contributes to the presentation of knowledge resources — information regarding barriers and opportunities to technology transfer oriented to sustainable development — so that governments and decision makers could define policies and strategies for a more effective process.