An Overview of Leishmaniasis: Historic to Future Perspectives

Abstract

Human leishmaniasis is a major public health problem with a wide clinical spectrum. Despite there is an epidemiological diversity of the disease, cases mostly occur in the developing countries around the subtropical region, and the incidence is significantly rising. The disease is usually classified into three groups: cutaneous leishmaniasis, mucosal leishmaniasis, and visceral leishmaniasis. But to ensure their survival in different conditions, Leishmania spp. have developed many adaptation mechanisms and can be seen in different clinical forms as well. Herein, an overview of the characteristics of the disease and the parasite, interactions with the host, clinical aspects, and latest developments in the diagnosis and treatment is presented.

Cutaneous Leishmaniasis Analyses in an Endemic Focus in Southwest Iran (2016-2020)

“…Many different types of leishmaniasis exist, including visceral, mucocutaneous, and cutaneous forms.CL is typically scarring when it is relatively basic, but it is not hazardous if left untreated; nevertheless, even when treated, mucocutaneous and diffuse cutaneous illness may develop in lethal secondary infections (7). Patients with CL may suffer from psychological and social problems, even though the disease is typically self-healing and does not threaten their lives (3,8,9). Leishmania species and the host's immunological response determine the infection period (acute to long-term) and its severity (6).…”