An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Dong, Bin; Zarlenga, Dante S.; Ren, Xiaofeng

doi:10.1155/2014/824630

Cited by 47 publications

(30 citation statements)

References 72 publications

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“…There is no specific treatment for acute PrV infection. Vaccination and concurrent antibiotic therapies are recommended for alleviation of clinical signs in pigs (12,13). Therefore, development of effective antiviral agents for prevention of PrV infection is necessary.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of resveratrol against pseudorabies virus-induced reproductive failure in a mouse model

Guo

et al. 2016

Food Sci Biotechnol

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Resveratrol (RES), a natural polyphenol that is abundant in grapes, exerts anti-inflammatory, anti-oxidative, and antiviral bioactive effects. Protective effects of RES against pseudorabies virus (PrV)- induced reproductive failure were investigated in a mice model. Injection of PrV partially induced stillbirth and abortion, and caused poor growth of progeny. Treatment with RES attenuated the reproductive failure induced by the virus with recovery of the serum progesterone level. RES improved the growth performance of newborn mice. RES can attenuate the reproductive failure induced by PrV in mice.

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Section: Introductionmentioning

confidence: 99%

Protective effect of resveratrol against pseudorabies virus-induced reproductive failure in a mouse model

Guo

et al. 2016

Food Sci Biotechnol

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“…Our and other laboratories have confirmed that live attenuated pseudorabies vaccines could stimulate strong cell-mediated immune responses and high titers of neutralizing antibody against PRV and were successfully used to control PRV infection [ 37 , 38 ]. Meanwhile, live attenuated PRV have been used as a highly economical promising candidate vector for the development of bivalent vaccine from animal viruses [ 39 , 40 ]. Xu et al had determined that PRV TK − /gE − /NS1 + expressed NS1 gene of JEV (SA14-14-2) could induce JEV-specific humoral and cellular immune responses [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype І

Qian

Zhi

Wang

et al. 2015

Virol J

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BackgroundJapanese encephalitis (JE) is an arboviral disease with high case fatality rates and neurologic or psychiatric sequelae among survivors in Asia, western Pacific countries and northern Australia. Japanese encephalitis virus (JEV) is the cause of JE and the emergence of genotype І (GI) JEV has displaced genotype III (GIII) as the dominant strains circulating in some Asian regions. The currently available JE vaccines are safe and effective in preventing this disease, but they are developed based on the GIII JEV strains.MethodsThe recombinant virus PRV TK−/gE−/PrM-E+ which expressed the premembrane (prM) and envelope (E) proteins of JEV SX09S-01 strain (genotype I, GI) was constructed by homologous recombination between the genome of PRV TK−/gE−/LacZ+ digested with EcoRI and plasmid pIE-CAG-PrM-E-BGH. Expression of JEV PrM and E proteins was analyzed by Western blot analysis. Immune efficacy of PRV TK−/gE−/PrM-E+ was further evaluated in mouse model.ResultsA recombinant pseudorabies virus (PRV TK−/gE−/PrM-E+) was successfully constructed. Mice experiments showed that PRV TK−/gE−/PrM-E+ could induce a high level of ELISA antibodies against PRV and JEV, as well as high titer of PRV neutralizing antibodies. After challenge with 1 × 107 PFU virulent JEV SX09S-01 strain, the time of death was delayed and the survival rate was improved in PRV TK−/gE−/PrM-E+ vaccinated mice.ConclusionsPRV TK−/gE−/PrM-E+ is a potential vaccine candidate against PRV and JEV GI infection in the future.

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“…A somewhat new vaccine design is the live recombinant vector vaccine (RVV), a chimera of two viral genomes. There are many flavors of these, and our focus is live, self-replicating vaccines in which the vector is a harmless virus whose genome is left largely intact except for inserts of foreign genes 12 , 10 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 . Its genome is engineered to carry one or a few antigenic genes from a pathogen.…”

Section: Recombinant Vector Vaccinesmentioning

confidence: 99%

Transmissible Viral Vaccines

Bull

Smithson

Nuismer

2018

Trends in Microbiology

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Genetic engineering now enables the design of live viral vaccines that are potentially transmissible. Some designs merely modify a single viral genome to improve on the age-old method of attenuation whereas other designs create chimeras of viral genomes. Transmission has the benefit of increasing herd immunity above that achieved by direct vaccination alone but also increases the opportunity for vaccine evolution, which typically undermines vaccine utility. Different designs have different epidemiological consequences but also experience different evolution. Approaches that integrate vaccine engineering with an understanding of evolution and epidemiology will reap the greatest benefit from vaccine transmission.

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An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Cited by 47 publications

References 72 publications

Protective effect of resveratrol against pseudorabies virus-induced reproductive failure in a mouse model

Protective effect of resveratrol against pseudorabies virus-induced reproductive failure in a mouse model

Construction and immune efficacy of recombinant pseudorabies virus expressing PrM-E proteins of Japanese encephalitis virus genotype І

Transmissible Viral Vaccines

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