An Overview of Multimodal Neuroimaging Using Nanoprobes

Sridhar, Srinivas; Mishra, Sachin; Gulyás, Miklós; Padmanabhan, Parasuraman; Gulyás, Balázs

doi:10.3390/ijms18020311

Cited by 10 publications

(6 citation statements)

References 45 publications

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“…The development of sensitive imaging and therapeutic probes that allow for facile diagnosis, diagnosis-driven treatment, and treatment monitoring of various diseases have recently attracted a great deal of attention 1 , 2 . Among the probes, nanometer-sized particles in particular have been extensively utilized as contrast agents for anatomical and functional in vivo imaging 3 . Many imaging techniques, such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), single photon emission computed tomography (SPECT), positron emission tomography (PET), ultrasound, optical imaging, and magnetic particle imaging (MPI) have been successfully used in preclinical research for noninvasive real-time monitoring of nanoprobe biodistribution in experimental animals 4 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Kostiv

Kučka

Lobaz

et al. 2020

Sci Rep

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Abstract“All-in-one” multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained on phantoms with different particle concentrations and during pilot long-time in vivo observations of a mouse model. The biological and physicochemical properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles make them promising as a trimodal optical/MRI/SPECT bioimaging and theranostic nanoprobe for experimental medicine.

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Section: Introductionmentioning

confidence: 99%

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Kostiv

Kučka

Lobaz

et al. 2020

Sci Rep

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“…[18] Besides, based on rational design and engineering, some commonly used nanoprobes, like QDs and carbon dots (CDs), enable chiral discrimination of drugs. [19] Previously, applications of luminescence nanoprobes in biological imaging, [20,21] biomolecular detection, [22] cancer imaging, [23][24][25] visualization of tumor microenvironments, [26] and diagnosis of cardiovascular disease [27] have been extensively reviewed. The involved nanoprobes include fluorescent nanoprobes, gold nanoprobes, SERS nanoprobes, [28] magnetic resonance imaging (MRI) nanoprobes, [29] and plasmonic nanoprobes.…”

Section: Luminescence Nanoprobes Applications Referencesmentioning

confidence: 99%

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Guo

et al. 2023

Advanced Sensor Research

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Luminescence nanoprobes have been extensively investigated for many biomedical applications, ranging from cell/tissue imaging, real‐time monitoring pathophysiological changes, drug discovery, bioassays, image‐guided surgery, and therapeutic evaluations, mainly due to their excellent physicochemical properties such as tailorable size, controlled morphology, and regulatable luminescence performances. In particular, rationally designed luminescence nanoprobes with reasonable functional integration enable pharmacological effect‐based drug screening, quantification of biological/pharmaceutical agents, and monitoring therapeutic responses of different drugs. This review provides an overview of the applications of different types of luminescence nanoprobes in drug discovery and development, involving various nanoprobes for high‐throughput and high‐content drug screening, pharmaceutical analysis, and therapeutic evaluations in cancers, cardiovascular diseases, and other typical inflammatory diseases. Moreover, challenges and future perspectives regarding future applications of luminescence nanoprobes in the drug discovery field are also discussed.

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“…The development of nanostructured contrast agents has also offered the prospect of simultaneously acquiring images using several imaging techniques or capturing images at different moments. Thus, the platform for multimodal imaging allows for benefiting from the advantages of each neuroimaging technique while overcoming their specific limitations [25].…”

Section: Introductionmentioning

confidence: 99%

Contrast Agents Delivery: An Up-to-Date Review of Nanodiagnostics in Neuroimaging

et al. 2019

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Neuroimaging is a highly important field of neuroscience, with direct implications for the early diagnosis and progression monitoring of brain-associated diseases. Neuroimaging techniques are categorized into structural, functional and molecular neuroimaging, each possessing advantages and disadvantages in terms of resolution, invasiveness, toxicity of contrast agents and costs. Nanotechnology-based approaches for neuroimaging mostly involve the development of nanocarriers for incorporating contrast agents or the use of nanomaterials as imaging agents. Inorganic and organic nanoparticles, liposomes, micelles, nanobodies and quantum dots are some of the most studied candidates for the delivery of contrast agents for neuroimaging. This paper focuses on describing the conventional modalities used for imaging and the applications of nanotechnology for developing novel strategies for neuroimaging. The aim is to highlight the roles of nanocarriers for enhancing and/or overcome the limitations associated with the most commonly utilized neuroimaging modalities. For future directions, several techniques that could benefit from the increased contrast induced by using imaging probes are presented.

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An Overview of Multimodal Neuroimaging Using Nanoprobes

Cited by 10 publications

References 45 publications

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Highly colloidally stable trimodal 125I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Luminescence Nanoprobes for Drug Screening, Pharmaceutical Analysis, and Therapeutic Evaluations

Contrast Agents Delivery: An Up-to-Date Review of Nanodiagnostics in Neuroimaging

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